{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:31:44Z","timestamp":1787063504259,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007218","name":"Verein fur Krebsforschung","doi-asserted-by":"publisher","award":["6421"],"award-info":[{"award-number":["6421"]}],"id":[{"id":"10.13039\/100007218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gastric cancer (GC) ranks among the most lethal epithelial malignancies, and its striking mortality rate prompts a global prevention strategy.\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>H. pylori<\/jats:italic>\n                    ) gastritis is the main GC promoter, and the 2014 Global Kyoto conference recognized\n                    <jats:italic>H. pylori<\/jats:italic>\n                    gastritis as a (treatable) infectious disease. It is therefore plausible that any large\u2010scale intervention for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication would result in cleansing the world of the fifth cause of cancer\u2010related death. Atrophic gastritis is the cancerization field in which GCs (both intestinal and diffuse histotypes) mainly develop. Discontinuing the inflammatory cascade triggered by\n                    <jats:italic>H. pylori<\/jats:italic>\n                    is tantamount to preventing GC. For patients (still infected or eradicated) who have already developed gastric atrophy, the severity\/topography of the atrophic changes correlates with their cancer risk. Gastritis OLGA (Operative Link for Gastritis Assessment) staging consistently ranks the atrophy\u2010associated cancer risk, providing a solid clinical\/biological rationale for establishing patient\u2010specific surveillance programs. By combining primary and secondary prevention strategies, gastric cancer is a preventable disease.\n                  <\/jats:p>","DOI":"10.1111\/hel.12571","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T23:30:40Z","timestamp":1550446240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-0563","authenticated-orcid":false,"given":"Massimo","family":"Rugge","sequence":"first","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit University of Padova Padova Italy"},{"name":"Veneto Tumor Registry (RTV) Veneto Regional Authority Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Sugano","sequence":"additional","affiliation":[{"name":"Department of Medicine Jichi Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Scarpignato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinical Pharmacology and Pathophysiology Unit School of Medicine and Dentistry University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walker Jove","family":"Oblitas","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Honorio Delgado Hospital Arequipa Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Giuseppe","family":"Naccarato","sequence":"additional","affiliation":[{"name":"Department of Translational Research and of New Surgical and Medical Technologies, Pathology Section University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5688"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.19"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. 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