{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:13:56Z","timestamp":1791670436740,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The eradication of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      ) has been suggested to reduce the risk of gastric cancer, but its impact on the gut microbiota has attracted public attention. This study aimed to investigate the short\u2010term and long\u2010term effects of bismuth quadruple therapy on both gastric and fecal microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten asymptomatic young adults with\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      \u2010related gastritis were treated with bismuth quadruple therapy for 14\u00a0days, and 7 age\u2010matched adults without\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      infection were enrolled as healthy controls. Both fecal and gastric mucosa samples were collected from\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      \u2010positive patients at weeks 0, 6, and 26, while fecal samples were collected from healthy controls. The gastric and gut microbiota were analyzed by 16S rRNA gene sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The structure of the gastric microbiota was significantly changed after the eradication of\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      with increased alpha diversity over time. The relative abundance of\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      sharply decreased from more than 70% to nearly 0% after treatment, while some beneficial bacteria, such as\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      , were increased. The microbial diversity of gut microbiota was higher in\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      \u2010infected patients than in healthy controls, which tended to decrease after eradication. The potentially beneficial gut bacteria\n                      <jats:italic>Blautia<\/jats:italic>\n                      and\n                      <jats:italic>Lachnoclostridium<\/jats:italic>\n                      were enriched at week 26 compared to week 0, while the pathogenic\n                      <jats:italic>Alistipes<\/jats:italic>\n                      were depleted to a level close to that of the healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Bismuth quadruple therapy for\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      eradication can restore the diversity of gastric microbiota with enrichment of beneficial bacteria. The composition of gut microbiota after\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      eradication trends toward healthy status instead of becoming dysbiotic.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12590","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:11:17Z","timestamp":1558656677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The eradication of\n                    <i>Helicobacter pylori<\/i>\n                    restores rather than disturbs the gastrointestinal microbiota in asymptomatic young adults"],"prefix":"10.1111","volume":"24","author":[{"given":"Cong","family":"He","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang 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