{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:41:38Z","timestamp":1791632498605,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873585"],"award-info":[{"award-number":["81873585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bismuth\u2010containing quadruple therapy (BQT) is a recommended alternative first\u2010line therapy for <jats:italic>Helicobacter pylori (H.\u00a0pylori)<\/jats:italic> infection. We aim to evaluate the efficacy and safety of a new BQT with amoxicillin and doxycycline as a first\u2010line treatment for <jats:italic>H.\u00a0pylori<\/jats:italic> infection in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open, prospective pilot clinical study\u00a0including <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive outpatients who had never received eradication treatment was carried out. An RADB regimen (10\u00a0mg rabeprazole, 1000\u00a0mg amoxicillin, 100\u00a0mg doxycycline, and 220\u00a0mg colloidal bismuth tartrate, all given bid for 14\u00a0days) was prescribed by gastroenterologists. <jats:italic>H.\u00a0pylori<\/jats:italic> eradication was confirmed by a <jats:sup>13<\/jats:sup>C\u2010urea breath test performed at least 6\u00a0weeks after the end of treatment. Regimen efficacy was evaluated by per\u2010protocol (PP) and intention\u2010to\u2010treat (ITT) analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eighteen patients were included in the study. The eradication rate of RADB was 93.8% (105\/112; 95% CI 89.2%\u201098.3%) in PP analysis and 89.8% (106\/118; 95% CI 84.3%\u201095.4%) in ITT analysis. The patient compliance rate was 97.5% (115\/118). The adverse event rate was 6.8% (8\/118). Adverse events included asthenia, loss of appetite, dry mouth, heartburn, diarrhea, and abdominal pain. All adverse events disappeared after completion\u00a0of\u00a0therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that 14\u2010day BQT with amoxicillin and doxycycline can be an effective and safe eradication regimen for first\u2010line therapy against <jats:italic>H.\u00a0pylori<\/jats:italic> infection in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12594","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:37:42Z","timestamp":1558622262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bismuth, rabeprazole, amoxicillin, and doxycycline as first\u2010line <i>Helicobacter pylori<\/i> therapy in clinical practice: A pilot study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-5459","authenticated-orcid":false,"given":"Lei","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-9696","authenticated-orcid":false,"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-4866","authenticated-orcid":false,"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-2927","authenticated-orcid":false,"given":"Huixiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital, Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12519"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"issue":"1372","key":"e_1_2_8_7_1","first-page":"e17","article-title":"Prevalence of antibiotic resistance in Helicobacter pylori: a systematic review and meta\u2010analysis in world health organization regions","volume":"155","author":"Savoldi A","year":"2018","journal-title":"Gastroenterology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12046"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i9.2786"},{"issue":"780","key":"e_1_2_8_10_1","first-page":"e5","article-title":"Primary antibiotic resistance of Helicobacter pylori in Chinese patients: a multiregion prospective 7\u2010year study","volume":"24","author":"Liu DS","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i8.2522"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12287"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1178065"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03386.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31409-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309900"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01498-13"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100960000288"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443683"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.99002.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1083-4389.2002.00066.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2008.04.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0374-z"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12209"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.306"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2017.05.002"},{"key":"e_1_2_8_28_1","first-page":"772","article-title":"Efficacy of bismuth containing quadruple therapies on Helicobacter pylori eradication in patients with history of antibiotic treatment","volume":"43","author":"Tang D","year":"2018","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12106"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i21.6698"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01910.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00649.x"},{"key":"e_1_2_8_33_1","first-page":"273","article-title":"Doxycycline\u2010based quadruple regimen versus routine quadruple regimen for rescue eradication of Helicobacter pylori: an open\u2010label control study in Chinese patients","volume":"53","author":"Wang ZH","year":"2012","journal-title":"Singapore Med J"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22339"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhel.12594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.12594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:53:36Z","timestamp":1694260416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/hel.12594"],"URL":"https:\/\/doi.org\/10.1111\/hel.12594","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"2019-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12594"}}