{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:54:31Z","timestamp":1761630871163,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National Research Foundation of Korea (NRF) grant for the Global Core Research Center (GCRC) funded by the Korea government","award":["2011-0030001"],"award-info":[{"award-number":["2011-0030001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of gastric atrophy is important in the regions where the prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) is high. The assessment of gastric atrophy is impossible in subjects with severe gastric inflammation or inadequate biopsy samples, leading these cases to be categorized as indefinite for atrophy. The aim of this study was to evaluate clinical characteristics of cases reported as indefinite for atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We reviewed 3192 gastric biopsies obtained at a single medical center between 2003 and 2017. Cases categorized as indefinite atrophy (n\u00a0=\u00a01,292) were compared with three groups, the absent atrophy group (n\u00a0=\u00a0755), Operative Link on Gastric Atrophy (OLGA) I\u2010II group (n\u00a0=\u00a0925), and OLGA III\u2010IV group (n\u00a0=\u00a0220), by considering age, sex, smoking, alcohol drinking, salty and spicy food diet, ABO blood type, family history of gastric cancer (GC), and <jats:italic>H. pylori<\/jats:italic> infection that are known atrophic gastritis\u2010associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects aged \u226565\u00a0years (34.9% vs 26.4%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), male (58.9% vs 49.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and <jats:italic>H. pylori<\/jats:italic> infected subjects (82.5% vs 63.3%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were significantly more likely to be categorized into the indefinite atrophy group than absent atrophy group. Subjects with family history of GC (21.9% vs 25.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031) and positive <jats:italic>H. pylori<\/jats:italic> infection (82.5% vs 86.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019) were significantly less likely to be in the indefinite atrophy group than low\u2010risk OLGA group. Subjects aged \u226565\u00a0years (34.9% vs 52.3%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and current\/past smoker (50.9% vs 70.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were significantly more likely to be in the high\u2010risk OLGA group than indefinite atrophy group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pathological report of indefinite for atrophy suggests a higher plausibility of gastric atrophy than nonassessment due to a simple technical error.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12605","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T06:23:49Z","timestamp":1563171829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The clinical meaning of the \u201cindefinite for atrophy\u201d lesions within gastric mucosa biopsy specimens in a region with a high prevalence of gastric cancer"],"prefix":"10.1111","volume":"24","author":[{"given":"Hee Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam South Korea"},{"name":"Department of Internal Medicine Myongji Hospital, Hanyang University College of Medicine Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-0406","authenticated-orcid":false,"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam South Korea"},{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Yong","family":"Yun","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Pathology Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2013first American cancer society award lecture on cancer epidemiology and prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer 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