{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:46:07Z","timestamp":1792194367281,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This review covers recent publications investigating the relationship between\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection and gastroesophageal reflux disease, Barrett's esophagus, eosinophilic esophagitis, peptic ulcer disease (\n                    <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                    ),\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    gastritis, and functional dyspepsia. In the area of gastroesophageal reflux disease, new data suggest that reflux may have a role in the transmission of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection. In addition to several observational studies, data on alterations in esophageal physiology in patients with\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection are presented. Further evidence for the inverse relationship between\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection and Barrett's esophagus is available in the form of a meta\u2010analysis from the North American Barrett's and Esophageal Carcinoma Consortium. The relationship between\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection and eosinophilic esophagitis remains uncertain. Although new data do not indicate a significantly lower prevalence of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    among patients with eosinophilic esophagitis, a meta\u2010analysis showed a 37% reduced risk of eosinophilic esophagitis among\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    \u2010infected patients. Novel data are presented on the genetic variability of bacterial virulence factors and their relationship with\n                    <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                    . We also report data on plasma biomarkers, which may detect progression to gastric cancer in\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    \u2010associated\n                    <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                    . A new meta\u2010analysis was published, which assessed the risk of\n                    <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                    in low\u2010dose aspirin users with\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection. Finally, we report on the ongoing attempts to stratify patients with gastritis using endoscopic methods when compared to standard biopsy examination.\n                  <\/jats:p>","DOI":"10.1111\/hel.12637","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T02:01:39Z","timestamp":1567648899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Review:\n                    <i>Helicobacter pylori<\/i>\n                    and non\u2010malignant upper gastrointestinal diseases"],"prefix":"10.1111","volume":"24","author":[{"given":"Doron","family":"Boltin","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Rabin Medical Center Petah Tikva, and the Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Niv","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Rabin Medical Center Petah Tikva, and the Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"The Ministry of Health of Israel  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology Niels\u2010Stensen\u2010Kliniken  Marienhospital, Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schulz","sequence":"additional","affiliation":[{"name":"Medical Department II University Hospital, LMU  Munich 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