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Divergent trends for <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> incidence were observed in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>. Incidence rates, particularly for non\u2010cardia <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, were stable or increasing among persons aged &lt;50\u00a0years. In an analysis of data from a public hospital database in Hong Kong, treatment of <jats:italic>Helicobacter pylori<\/jats:italic> infection was associated with a lower risk of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, particularly in older subjects who received treatment \u226510\u00a0years before. Based on the results of a 16\u2010year endoscopy\u2010based follow\u2010up eradication trial, patients with incomplete\u2010type intestinal metaplasia (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) should receive endoscopic surveillance upon <jats:italic>H. pylori<\/jats:italic> eradication therapy. Updated guidelines on the endoscopic surveillance of preneoplastic conditions of the stomach (<jats:styled-content style=\"fixed-case\">MAPS II<\/jats:styled-content>) have been published. In the <jats:styled-content style=\"fixed-case\">RAINFALL<\/jats:styled-content> trial, the addition of ramucirumab to a backbone chemotherapy as a first\u2010line regimen failed to improve overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) of patients with metastatic disease. Also, pembrolizumab did not prolong <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> when compared to paclitaxel in the second\u2010line treatment of patients with advanced <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> or esophagogastric junction (<jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>) cancer. Trifluridine\/tipiracil improved <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> by 2.1\u00a0months in the third or further treatment line of patients with advanced <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>. In a systematic investigation conducted on Chinese patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CLDN<\/jats:styled-content>18\u2010<jats:styled-content style=\"fixed-case\">ARHGAP<\/jats:styled-content>26\/6 fusion was associated with signet\u2010ring cell content and was prognostic for a worse outcome and predictive for no benefit from oxaliplatin\/fluoropyrimidine\u2010based chemotherapy. Organoid cultures represent an appealing model that may be applied for therapy response testing in the near future.<\/jats:p>","DOI":"10.1111\/hel.12643","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T06:01:39Z","timestamp":1567663299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Review: Gastric cancer\u2014Clinical aspects"],"prefix":"10.1111","volume":"24","author":[{"given":"Marino","family":"Venerito","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University Hospital  Magdeburg 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