{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:47:57Z","timestamp":1783129677219,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>IL\u201027 has dual roles in the immune response either stimulating Th1 or inhibiting Th17 cells. Because there is a particular link of IL\u201023\/Th17 axis in the development of cancer and IL\u201027 has been considered a potential treatment for cancer, we evaluated the gastric and serum concentrations of IL\u201027 in two mutually exclusive <jats:italic>Helicobacter pylori\u2010<\/jats:italic>associated diseases, gastric cancer (GC) and duodenal ulcer (DU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We prospectively studied 110 <jats:italic>H\u00a0pylori<\/jats:italic>\u2010positive patients and 40 healthy blood donors. Serum and gastric concentrations of IL\u201027 and cytokines of the Th1\/Th17 cells were assessed by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u201027 was not detected in GC patients, but the cytokine concentration was very high in the patients with DU. IL\u201027 was also detected in the gastritis patients and in the <jats:italic>H\u00a0pylori<\/jats:italic>\u2010positive blood donors. <jats:italic>IL27RA<\/jats:italic> mRNA expression in peripheral blood mononuclear cells, evaluated by rt\u2010PCR, was stimulated by <jats:italic>H\u00a0pylori<\/jats:italic> strains. The cytokine concentration positively correlated with the Th1 and negatively with Th17 cell representative cytokine levels. Gastric IL\u201027 concentrations were positively correlated with increased degree of mononuclear and polymorphonuclear cells on the antral gastric mucosa of DU patients in consonance with the DU gastritis pattern. IL\u201012p70 and IFN\u2010\u03b3 gastric concentrations were significantly higher in DU than in GC. Conversely, gastric concentrations of Th17 cell\u2010associated cytokines (IL\u20101\u03b2, IL\u20106, IL\u201017A, IL\u201023, and TGF\u2010\u03b2) were significantly higher in GC than in DU patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although <jats:italic>H\u00a0pylori<\/jats:italic> infection is able to elicit IL\u201027 and IL\u201027R\u03b1 secretion, DU and GC have diametrically opposed cytokine patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12667","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T10:25:21Z","timestamp":1573208721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Interleukin\u201027 is abrogated in gastric cancer, but highly expressed in other <i>Helicobacter pylori\u2010<\/i>associated gastroduodenal diseases"],"prefix":"10.1111","volume":"25","author":[{"given":"Gifone A.","family":"Rocha","sequence":"first","affiliation":[{"name":"Laboratory of Research in Bacteriology Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio F.","family":"de Melo","sequence":"additional","affiliation":[{"name":"Instituto Multidisciplinar em Sa\u00fade Universidade Federal da Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica M. 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