{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:08:55Z","timestamp":1790611735292,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2020,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Experience in\n Helicobacter pylori<\/jats:italic>\n eradication treatment of patients allergic to penicillin is very scarce. A triple combination with a PPI, clarithromycin (C), and metronidazole (M) is often prescribed as the first option, although more recently the use of a quadruple therapy with PPI, bismuth (B), tetracycline (T), and M has been recommended.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To evaluate the efficacy and safety of first\u2010line and rescue treatments in patients allergic to penicillin in the \u201cEuropean Registry of\n H\u00a0pylori<\/jats:italic>\n management\u201d (Hp\u2010EuReg).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A systematic prospective registry of the clinical practice of European gastroenterologists (27 countries, 300 investigators) on the management of\n H\u00a0pylori<\/jats:italic>\n infection. An e\u2010CRF was created on AEG\u2010REDCap. Patients with penicillin allergy were analyzed until June 2019.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One\u2010thousand eighty\u2010four patients allergic to penicillin were analyzed. The most frequently prescribed first\u2010line treatments were as follows: PPI\u00a0+\u00a0C\u00a0+\u00a0M (n\u00a0=\u00a0285) and PPI\u00a0+\u00a0B\u00a0+\u00a0T\u00a0+\u00a0M (classic or Pylera\n \u00ae<\/jats:sup>\n ; n\u00a0=\u00a0250). In first line, the efficacy of PPI\u00a0+\u00a0C\u00a0+\u00a0M was 69%, while PPI\u00a0+\u00a0B\u00a0+\u00a0T\u00a0+\u00a0M reached 91% (\n P<\/jats:italic>\n \u00a0<\u00a0.001). In second line, after the failure of PPI\u00a0+\u00a0C\u00a0+\u00a0M, two rescue options showed similar efficacy: PPI\u00a0+\u00a0B\u00a0+\u00a0T\u00a0+\u00a0M (78%) and PPI\u00a0+\u00a0C\u00a0+\u00a0levofloxacin (L) (71%) (\n P<\/jats:italic>\n \u00a0>\u00a0.05). In third line, after the failure of PPI\u00a0+\u00a0C\u00a0+\u00a0M and PPI\u00a0+\u00a0C\u00a0+\u00a0L, PPI\u00a0+\u00a0B\u00a0+\u00a0T\u00a0+\u00a0M was successful in 75% of cases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In patients allergic to penicillin, a triple combination with PPI\u00a0+\u00a0C\u00a0+\u00a0M should not be generally recommended as a first\u2010line treatment, while a quadruple regimen with PPI\u00a0+\u00a0B\u00a0+\u00a0T\u00a0+\u00a0M seems to be a better option. As a rescue treatment, this quadruple regimen (if not previously prescribed) or a triple regimen with PPI\u00a0+\u00a0C\u00a0+\u00a0L could be used but achieved suboptimal (<80%) results.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.12686","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T04:56:16Z","timestamp":1584334576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Helicobacter pylori<\/i>\n first\u2010line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on\n H\u00a0pylori<\/i>\n management (Hp\u2010EuReg)"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-9310","authenticated-orcid":false,"given":"Olga P.","family":"Nyssen","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010IP) Hospital Universitario de La Princesa Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"P\u00e9rez\u2010Aisa","sequence":"additional","affiliation":[{"name":"Digestive Unit Agencia Sanitaria Costa del Sol Marbella Spain"},{"name":"Red de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas (REDISSEC) M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Tepes","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit AM DC Rogaska Rogaska Slatina Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Rodrigo\u2010S\u00e1ez","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Hospital Universitario Central de Asturias Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar M.","family":"Romero","sequence":"additional","affiliation":[{"name":"Hospital San Pedro de Alc\u00e1ntara C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Hospital de Tomelloso (Ciudad Real) Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Castro\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital de Valme Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perminder","family":"Phull","sequence":"additional","affiliation":[{"name":"Aberdeen Royal Infirmary Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Barrio","sequence":"additional","affiliation":[{"name":"Hospital R\u00edo Hortega Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Hospital Donostia\/Instituto Biodonostia Universidad del Pa\u00eds Vasco (UPV\/EHU) Donosti Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ortu\u00f1o","sequence":"additional","affiliation":[{"name":"Hospital Universitari i Polit\u00e8cnic La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Areia","sequence":"additional","affiliation":[{"name":"Portuguese Oncology Institute Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Brglez Jurecic","sequence":"additional","affiliation":[{"name":"Diagnostic Centre Bled Bled Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Huguet","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Alcaide","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Valladolid Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Voynovan","sequence":"additional","affiliation":[{"name":"Department of Pancreatobiliary and Upper GI Diseases Moscow Clinical Scientific Center A.I. 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