{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:11:05Z","timestamp":1789582265659,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Analysis of serum biomarkers for the assessment of atrophic gastritis (AG), considered as gastric precancerous lesion, is of growing interest and recommended by current guidelines. Our aim was to evaluate the diagnostic performance of a panel of biomarkers (GastroPanel\u00ae) for the detection of AG in France, a country of a low gastric cancer (GC) incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this prospective, multicenter, cross\u2010sectional study, consecutive patients considered at increased risk of GC and undergoing upper endoscopy with gastric biopsies were included. Blood samples were collected for the analysis of GastroPanel\u00ae (association of Pepsinogens I and II, Gastrin\u201017, and <jats:italic>Helicobacter pylori<\/jats:italic> serology) using ELISA. The results of GastroPanel\u00ae were compared to the results of histology considered as the reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2016 and 2019, 344 patients (148 cases with AG, 196 controls without AG) were included. Sensitivity, specificity, positive, and negative predictive values for the detection of AG by GastroPanel\u00ae were of 39.9% (95% CI 31.9; 48.2), 93.4% (95% CI 88.9; 96.4), 81.9 (95% CI 71.1; 90.0), and 67.3 (95% CI 61.4; 72.8), respectively. The sensitivity was significantly higher for the detection of severe AG [60.8% (95% CI 46.1; 74.6) <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015] and corpus AG [61.0% (95% CI 49.2; 72.0), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004]. Diagnostic performances of GastroPanel\u00ae tended to be better than those of Pepsinogen I alone, but the difference did not reach statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.068).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum pepsinogen and GastroPanel\u00ae tests show promising results for the detection of AG, especially of corpus AG and severe AG, in patients at high risk of GC in France.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12727","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T08:53:47Z","timestamp":1595494427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A panel of stomach\u2010specific biomarkers (GastroPanel\u00ae) for the diagnosis of atrophic gastritis: A prospective, multicenter study in a low gastric cancer incidence area"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-9693","authenticated-orcid":false,"given":"Nicolas","family":"Chapelle","sequence":"first","affiliation":[{"name":"IMAD Hepato\u2010Gastroenterology &amp; Digestive Oncology Unit University Hospital of Nantes Nantes France"},{"name":"University of Nantes Nantes France"},{"name":"INSERM UMR1235 The Enteric Nervous System in Gut and Brain Disorders Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Petryszyn","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Blin","sequence":"additional","affiliation":[{"name":"University of Nantes Nantes France"},{"name":"INSERM UMR1235 The Enteric Nervous System in Gut and Brain Disorders Nantes France"},{"name":"Department of Biochemistry University Hospital of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Leroy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University Hospital of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Le Berre\u2010Scoul","sequence":"additional","affiliation":[{"name":"University of Nantes Nantes France"},{"name":"INSERM UMR1235 The Enteric Nervous System in Gut and Brain Disorders Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Jirka","sequence":"additional","affiliation":[{"name":"IMAD Hepato\u2010Gastroenterology &amp; Digestive Oncology Unit University Hospital of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Neunlist","sequence":"additional","affiliation":[{"name":"University of Nantes Nantes France"},{"name":"INSERM UMR1235 The Enteric Nervous System in Gut and Brain Disorders Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Driffa","family":"Moussata","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology University Hospital of Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Lamarque","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology Ambroise\u2010Par\u00e9 Hospital AP\u2010HP Paris Saclay University UVSQ INSERM, Infection and Inflammation Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Olivier","sequence":"additional","affiliation":[{"name":"IMAD Hepato\u2010Gastroenterology &amp; 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