{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:30:35Z","timestamp":1789425035653,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This review takes into account recent publications focusing on the relationship between\u00a0\n                    <jats:italic>Helicobacter pylori\u00a0<\/jats:italic>\n                    infection and non\u2010malignant diseases of the upper gastro\u2010intestinal tract. The authors have summarized current knowledge on associations between the\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection and non\u2010malignant upper GI conditions including gastroesophageal reflux disease (GERD), Barrett's esophagus, eosinophilic esophagitis (EOE), peptic ulcer disease (PUD),\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    gastritis, celiac disease and functional dyspepsia. In the field of GERD, current data focusing on different locations of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection detect significant differences between antrum\u2010 and corpus predominant gastritis explainable by different changes in acid secretion in different gastric niches. High volume studies from Sweden and Brazil underline the safety of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    eradication concerning the risk of Barret's esophagus or adenocarcinoma. The relationship between\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    infection and EOE remains uncertain, but current data supports the concept of expected positive and protective effects of\n                    <jats:italic>H\u00a0pylori<\/jats:italic>\n                    exposure reducing the risk of EOE. Analyzing biomarkers might be helpful to identify subjects under risk for the development of precancerous lesions after\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection, where microRNAs, IL\u20109 and IL\u20104, and also Tc17\/9 and Th17\/9 and microbiota profiles showed promising results to identify subgroups under risk.\n                  <\/jats:p>","DOI":"10.1111\/hel.12738","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T03:16:45Z","timestamp":1600312605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Review \u2010\n                    <i>Helicobacter pylori<\/i>\n                    and non\u2010malignant upper gastro\u2010intestinal diseases"],"prefix":"10.1111","volume":"25","author":[{"given":"Christian","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Medicine II University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juozas","family":"Kup\u010dinskas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Institute for Digestive Research Lithuanian University of Health Sciences  Kaunas 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