{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:51:55Z","timestamp":1792007515398,"version":"4.4.0"},"reference-count":97,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The involvement of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection in many extra\u2010gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      with extra\u2010gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term \u201cHelicobacter\u201d in the MEDLINE\/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non\u2010alcoholic steatohepatitis, neurology, including Parkinson\u2019s disease and Alzheimer\u2019s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn\u2019s disease and ulcerative colitis, may originate from a dysregulation of the host\u2019s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between\n                      <jats:italic>H\u00a0pylori<\/jats:italic>\n                      infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of\n                      <jats:italic>H<\/jats:italic>\n                      \u00a0\n                      <jats:italic>pylori<\/jats:italic>\n                      infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12741","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T06:31:01Z","timestamp":1613629861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Review: Extragastric diseases and\n                    <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"25","author":[{"given":"Rinaldo","family":"Pellicano","sequence":"first","affiliation":[{"name":"Unit of Gastroenterology Molinette\u2010SGAS Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Ianiro","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Fondazione Policlinico Universitario Agostino Gemelli IRCCS Catholic 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