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The aim of the current study was to examine the association in Guatemala, a region with elevated prevalences of both <jats:italic>H\u00a0pylori<\/jats:italic> and NAFLD. Associations between <jats:italic>H\u00a0pylori<\/jats:italic> and other metabolic conditions were also examined, as were associations between <jats:italic>H\u00a0hepaticus<\/jats:italic> and <jats:italic>H\u00a0bilis<\/jats:italic> and the metabolic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>The analysis included 424 participants from a cross\u2010sectional study in Guatemala. <jats:italic>H\u00a0pylori<\/jats:italic> seropositivity was defined as positivity for\u00a0\u2265\u00a04 antigens. Seropositivities for <jats:italic>H\u00a0bilis<\/jats:italic> and <jats:italic>H\u00a0hepaticus<\/jats:italic> were defined as positivity for\u00a0\u2265\u00a02 antigens. NAFLD was estimated using the Fatty Liver Index and the Hepatic Steatosis Index. Other conditions examined were obesity, central obesity, hypercholesterolemia, low HDL, diabetes and metabolic syndrome (MetSyn). Prevalence odds ratios (POR) and 95% confidence intervals (CIs) were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No overall associations between <jats:italic>H\u00a0pylori<\/jats:italic>,<jats:italic>H\u00a0hepaticus<\/jats:italic>, or <jats:italic>H\u00a0bilis<\/jats:italic> and NAFLD or related metabolic conditions were found. Seropositivity for <jats:italic>H\u00a0pylori<\/jats:italic> antigens CagA and VacA and <jats:italic>H\u00a0hepaticus<\/jats:italic> antigen HH0713 was each significantly associated with NAFLD, however. In addition, associations were observed between the <jats:italic>H\u00a0pylori<\/jats:italic> antigens HyuA, HP1564, and UreA and specified metabolic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While no overall associations between <jats:italic>H\u00a0pylori<\/jats:italic> or <jats:italic>Helicobacter<\/jats:italic> species with NAFLD or related conditions were observed, some selected <jats:italic>Helicobacter<\/jats:italic> spp. antigens were associated with NAFLD. Further research is warranted to examine whether <jats:italic>H<\/jats:italic>. species are associated with any metabolic condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12756","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T13:18:41Z","timestamp":1601644721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Associations between <i>Helicobacter pylori<\/i> with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-0444","authenticated-orcid":false,"given":"Christian S.","family":"Alvarez","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea 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