{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:57:36Z","timestamp":1789498656913,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eradication rates of<jats:italic>Helicobacter pylori<\/jats:italic>(<jats:italic>H\u00a0pylori<\/jats:italic>) with standard triple therapy are gradually decreasing all over the world, including in children, due to the development of strains resistant to antimicrobials. Sequential therapy can be used as an alternative method to increase eradication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 75 patients\u00a0\u2265\u00a08\u00a0years of age with<jats:italic>H\u00a0pylori<\/jats:italic>gastritis were included in the study. According to Rome IV criteria, 38 patients had functional abdominal pain and dyspepsia, and 37 patients had alarm findings suggesting organic disease. Patients were treated with a novel sequential therapy consisting of the proton pump inhibitor (PPI)\u2010lansoprazole (1\u00a0mg\/kg\/day, maximum 30\u00a0mg daily), amoxicillin (50\u00a0mg\/kg\/d in two doses, maximum 2\u00a0\u00d7\u00a01000\u00a0mg) for 7\u00a0days followed by PPI\u2010lansoprazole (1\u00a0mg\/kg\/d, maximum 30\u00a0mg daily), metronidazole (20\u00a0mg\/kg\/day in two doses, maximum 2 x 500\u00a0mg), tetracycline (50\u00a0mg\/kg\/d divided into four equal doses, maximum 4 x 500\u00a0mg), and bismuth subsalicylate (262\u00a0mg QID in patients\u00a0\u2264\u00a010\u00a0years of age, 524\u00a0mg QID in patients\u00a0&gt;\u00a010\u00a0years of age in days 8\u201014). Eradication status was evaluated by<jats:italic>H\u00a0pylori<\/jats:italic>stool antigen test 8\u00a0weeks after the completion of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 15.1\u00a0\u00b1\u00a02.4\u00a0years and 51 (68%) were female. No patient discontinued therapy due to side effects. All patients had antral gastritis (76.0%) or pangastritis (24.0%). The peptic ulcer rate was 6.6%. Eradication therapy was given to all patients with or without peptic ulcer.<jats:italic>H\u00a0pylori<\/jats:italic>eradication was achieved in 69 (92.0%) patients and symptoms improved in 61 of those eradicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As a first\u2010line treatment for<jats:italic>H\u00a0pylori<\/jats:italic>eradication in children, administering a novel sequential therapy including bismuth for 14\u00a0days provides a high rate of eradication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12757","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T09:55:30Z","timestamp":1600336530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of a novel sequential treatment regimen containing bismuth for<i>Helicobacter pylori<\/i>eradication in Turkish children"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-4699","authenticated-orcid":false,"given":"Melike","family":"Arslan","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology Department of Pediatrics University of Health Sciences G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necati","family":"Balamtekin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Department of Pediatrics University of Health Sciences G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arma\u011fan","family":"G\u00fcnal","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Health Sciences G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i31.3472"},{"issue":"8","key":"e_1_2_7_3_1","first-page":"65","article-title":"How and when investigating and treating Helicobacter pylori infection in children","volume":"89","author":"Marco M","year":"2018","journal-title":"Acta Biomed"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-1215"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"e12639","DOI":"10.1111\/hel.12639","article-title":"Review: Helicobacter pylori in pediatrics","volume":"24","author":"Mi\u0161ak Z","year":"2019","journal-title":"Helicobacter"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001594"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"87","article-title":"Helicobacter pylori treatment in Turkey: Current status and rational treatment options","volume":"7","author":"Kaplan M","year":"2020","journal-title":"North Clin Istanb"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.555"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2012.00989.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2017.05.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1438188"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.1997.06b09.x"},{"key":"e_1_2_7_14_1","first-page":"405425","article-title":"Modified Sequential Therapy Regimen versus Conventional Triple Therapy for Helicobacter Pylori Eradication in Duodenal Ulcer Patients in China: A Multicenter Clinical Comparative Study","volume":"2012","author":"Zhou Y\u2010Q","year":"2012","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00033.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12497"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200203000-00010"},{"issue":"43","key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.3748\/wjg.v18.i43.6250","article-title":"Stefano Valabrega. 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