{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:26Z","timestamp":1753878566289,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic>(<jats:italic>H pylori<\/jats:italic>) infection is the most common cause of gastritis. The disappearance of regular arrangement of collecting venules (RAC) is well known as one of the main manifestations of<jats:italic>H pylori<\/jats:italic>\u2010affected gastritis while the reason behind it remains obscure. The aim of this study was to investigate the relationship between invisibility of RAC and the length of gastric foveolae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>43 RAC\u2010positive and 118 RAC\u2010negative patients were enrolled. Gastric biopsy specimens were obtained from lesser and greater curvature of the corpus with RAC\u2010positive or RAC\u2010negative pattern. Histopathological evaluation was performed based on the updated Sydney System, and foveolar length was derived by a morphometric technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median gastric foveolar length in RAC\u2010positive group (median [IQR], 138.54\u00a0\u03bcm [120.50, 159.09]) was significantly shorter than that in the RAC\u2010negative group (median [IQR], 260.96\u00a0\u03bcm [217.40, 315.23],<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The length of gastric foveolae in chronic active gastritis (RAC\u2010negative, activity grades 1, 2, and 3) and inactive gastritis (RAC\u2010negative, activity grade 0) was longer than that in normal group (RAC\u2010positive, activity grade 0) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The optimal cutoff value for gastric foveolae length of the corpus mucosa showing RAC\u2010negative pattern was more than 181.53\u00a0\u03bcm. The sensitivity and specificity of more than cutoff value for predicting the invisibility of RAC were 93.03% and 91.78%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The elongation of gastric foveolae caused the invisibility of RAC in gastric corpus mucosa in chronic active and inactive gastritis on gastroendoscopy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12770","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T12:25:51Z","timestamp":1605270351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gastric foveolar elongation causes invisibility of regular arrangement of collecting venules in chronic active and inactive gastritis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-5819","authenticated-orcid":false,"given":"Cong","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of North Sichuan Medical College Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Mei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology Basic Medical College of North Sichuan Medical College Nanchong China"},{"name":"Department of Pathology Affiliated Hospital of North Sichuan Medical College Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China School of public health West China Forth Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China School of public health West China Forth Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China School of public health West China Forth Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology West China School of public health West China Forth Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology West China School of public health West China Forth Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1053\/j.gastro.2017.04.022"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1111\/j.1523-5378.2009.00650.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1111\/jgh.12046"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1055\/a-0999-5252"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1007\/s00535-005-1605-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1055\/s-2006-945056"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1046\/j.1443-1661.14.s1.10.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1055\/s-2005-861423"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1097\/01.MP.0000062995.72390.14"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1111\/hel.12487"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1067\/mge.2003.316"},{"doi-asserted-by":"crossref","unstructured":"DixonMF GentaRM YardleyJH et al. 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