{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:47:56Z","timestamp":1792504076569,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> infection among orthotopic liver transplant (LT) recipients and explore the efficacy and safety of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> eradication therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Liver transplant recipients receiving regular follow\u2010up in our center were assessed by 13C\u2010urea breath test between February 2018 and July 2020. A group of healthy tested patients were selected as control group at a rate of 1:3. All LT recipients with <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> were recommended to receive eradication therapy with bismuth\u2010containing quadruple therapy (BQT), which included esomeprazole 20\u00a0mg\u00a0+\u00a0clarithromycin 500\u00a0mg\u00a0+\u00a0amoxicillin 1\u00a0g\u00a0+\u00a0bismuth 220\u00a0mg, twice daily for 14\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> infection among the LT recipients was 19.6% (30\/153), which was significantly lower than the control group (30\/153 [19.6%] vs. 200\/459 [43.6%], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In LT recipients who received transplantation at &lt;1\u00a0year, 1\u20133\u00a0years, and &gt;3\u00a0years, the prevalence of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection was 10.6% (5\/47), 17.5% (10\/57), and 30.6% (15\/49), respectively, which increased with the time after transplantation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). With BQT, the eradication rate of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> was 91.3% (21\/23). During the process of eradication, the blood trough concentration of immunosuppressants increased from 1.7 to 3.6 times, and reducing the dose of the drugs to one\u2010third of what they were before the eradication therapy could avoid excessively elevated concentration of immunosuppressants. Adverse effects occurred in 55.2% (11\/23), of the LT recipients and 21.0% (42\/200) of the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), which was probably caused by the increased blood concentration of immunosuppressants. Normal liver function was observed, while transient abnormal kidney function was occurred in one recipient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> infection was 19.6% among the LT recipients, which increased with the postoperative time. With BQT, <jats:italic>H. pylori<\/jats:italic> eradication was safe and effective in LT recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12791","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T19:51:58Z","timestamp":1613850718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary single\u2010center experience of <i>Helicobacter pylori<\/i> eradication among the liver transplant recipients"],"prefix":"10.1111","volume":"26","author":[{"given":"Man","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology Medical College of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Hepatology Liver Disease Center The Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Organ Transplantation The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Ju","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Hepatology Liver Disease Center The Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Organ Transplantation The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Hepatology Liver Disease Center The Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Organ Transplantation The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010jin","family":"Zang","sequence":"additional","affiliation":[{"name":"Division of Hepatology Liver Disease Center The Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Organ Transplantation The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-583X","authenticated-orcid":false,"given":"Wei","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Hepatology Liver Disease Center The Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Organ Transplantation The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23722"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.12.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-018-1628-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25310"},{"key":"e_1_2_9_6_1","first-page":"w20078","article-title":"Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study","volume":"149","author":"Lengwiler E","year":"2019","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.897595"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.12.001"},{"key":"e_1_2_9_9_1","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. 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