{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:05:22Z","timestamp":1767164722351,"version":"build-2238731810"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Helicobacter pylori (HP) infection is reported to increase\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluoro\u20102\u2010deoxyglucose (FDG) accumulation in the stomach. The accumulation of FDG by positron\u2010emission tomography (FDG\u2010PET) in the stomach for the voluntary health examinees of cancer checkup was examined before and after the HP eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>From March 2013 to October 2015, eighty\u2010one subjects were performed FDG\u2010PET to detect cancer at the health checkup. All of them were also surveyed by esophagogastroduodenoscopy. Subjects were classified as the 33 cases of HP positive (group A), 38 cases of originally negative (group B), and the 10 negative cases by HP eradication therapy (group C). Group A was treated by combination of amoxicillin, clarithromycin, and proton pump inhibitor for a week, and all of them eradicated HP. A part of group A (n\u00a0=\u00a07) was serially performed FDG\u2010PET one to five years after the treatment and compared the maximum standard uptake value of FDG (SUV) around the fundic gland region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SUV of group A (3.55\u00a0\u00b1\u00a00.69) was significantly higher than those of both group B (2.96\u00a0\u00b1\u00a00.72) and group C (2.89\u00a0\u00b1\u00a00.51) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, respectively). Groups B and C are almost comparable and showed no significant difference during the course. In group A, HP eradication significantly decreased the SUV to 3.1\u00a0\u00b1\u00a00.43 (P\u00a0&lt;\u00a0.01). SUV after the eradication was significantly reduced (P\u00a0&lt;\u00a0.01) in the mild to moderate atrophy (C1\u2013C3) group according to Kimura and Takemoto classification of chronic gastritis of group A. Although SUV in the advanced atrophy group (O1\u2013O3) tended to decline after the eradication, the change was not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HP\u2010infected stomach showed higher FDG uptake in the fundic gland region and HP eradication decreased the uptake in the mild to moderate atrophic gastritis but not in the severe atrophic gastritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12797","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T07:15:23Z","timestamp":1615187723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes of\n                    <sup>18<\/sup>\n                    F\u2010fluoro\u20102\u2010deoxyglucose position\u2010emission tomography findings by the eradication of Helicobacter pylori in the stomach"],"prefix":"10.1111","volume":"26","author":[{"given":"Kyoko","family":"Marubashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takakusagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yozo","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Kizawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kosone","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-1170","authenticated-orcid":false,"given":"Hitoshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kusunoki Hospital Fujioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-006-0595-0"},{"key":"e_1_2_5_3_1","first-page":"4103","article-title":"Application of PET and PET\/CT imaging for cancer screening","volume":"24","author":"Chen YK","year":"2004","journal-title":"Anticancer Res"},{"key":"e_1_2_5_4_1","first-page":"3036","article-title":"The use of (18)F\u2010FDG\u2010PET\/CT for diagnosis and treatment monitoring of inflammatory and infectious diseases","volume":"62","author":"Glaudemans AW","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000247742.52969.6b"},{"key":"e_1_2_5_6_1","first-page":"85","article-title":"Factors affecting gastric uptake in whole body FDG\u2010PET imaging","volume":"28","author":"Tomemori T","year":"2001","journal-title":"J 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