{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:56:45Z","timestamp":1769767005195,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic>) infection\u2010related diseases, peptic ulcer, and gastric cancer are frequently asymptomatic until the onset of complications. This study aimed to investigate the prevalence of <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic>, erosive esophagitis, peptic ulcer, and precancerous lesions such as atrophic gastritis, intestinal metaplasia, gastric dysplasia, and upper gastrointestinal (GI) malignancy in asymptomatic Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January to December 2017, a questionnaire was administered to consecutive asymptomatic patients undergoing routine physical examination, which included their first screening esophagogastroduodenoscopy. <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> infection was determined by one of positive <jats:sup>13<\/jats:sup>C urea breath tests or rapid urease test and histology. The presence of <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> infection, erosive esophagitis, peptic ulcer, precancerous gastric histology, and upper GI malignancy was analyzed in relation to demographic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1108 subjects (mean age: 48, range 21 to 79, 39.5% men) were included. The findings were: erosive esophagitis 7.8%, active <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> infection 44%, peptic ulcer 9.1% (duodenal 5.8%, gastric 2.5% or both 0.8%); 0.5% had gastric cancer. Male, smoking history, and current <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> infection were all significantly related to the presence of peptic ulcer. Totally, 1095 patients had gastric histopathology and premalignant gastric lesions were present in 67.4%; atrophic gastritis (67.4%), intestinal metaplasia (27.4%), and gastric dysplasia (0.5%). Age, current and previous <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> infection were risk factors significantly associated with precancerous lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Upper GI pathology as a sequelae of <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> infection is common in asymptomatic Chinese. These findings support institution of a nationwide test and treat program to eradicate <jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic> in China.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12803","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T08:10:07Z","timestamp":1617005407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lessons learned from upper gastrointestinal endoscopy in asymptomatic Chinese"],"prefix":"10.1111","volume":"26","author":[{"given":"Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-3764","authenticated-orcid":false,"given":"Huiyi","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-0767","authenticated-orcid":false,"given":"Xiaohua","family":"Long","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-6048","authenticated-orcid":false,"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Clinical Research Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.324"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.10.003"},{"key":"e_1_2_7_4_1","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2013First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32404-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01311-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1542299"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"243","article-title":"Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long\u2010term cohort study on Matsu Islands","volume":"70","author":"Chiang TH","year":"2020","journal-title":"Gut"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15091"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2015.30.2.133"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21664"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i8.2460"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.026"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.618"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i19.2950"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13842"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302240"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15187"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322368"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.12803","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T14:15:37Z","timestamp":1693577737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/hel.12803"],"URL":"https:\/\/doi.org\/10.1111\/hel.12803","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"assertion":[{"value":"2021-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12803"}}