{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:17:52Z","timestamp":1756383472350,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010<jats:italic>Helicobacter pylori Helicobacter<\/jats:italic> (NHPH) is not widely recognized as a cause of acute gastric mucosal lesions (AGML), as only a few cases of AGML caused by NHPH have been reported. We present here one case and examine the species and eradication of NHPH together with the three previously reported cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 52\u2010year\u2010old woman presented with a two\u2010day history of severe epigastric pain, nausea, and vomiting. An esophagogastroduodenoscopy showed mucosal edema, multiple erosions, and ulcerations in the antrum. Biopsy specimens taken from the antrum revealed long spiral\u2010shaped organisms, suggesting NHPH. As both serum anti\u2010<jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>) antibody and <jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic> stool antigen test were negative, this case was diagnosed as AGML caused by NHPH. After the administration of esomeprazole 20\u00a0mg for 14\u00a0days and the interval of the following 12\u00a0days, AGML was deemed to have been cured endoscopically. In addition, microscopic examination and PCR analysis confirmed the success of NHPH eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NHPH should be considered a probable cause of AGML in cases that are not attributed to the other causes already recognized. Taking probability of spontaneous eradication into consideration, it is appropriate to start eradication therapy after confirming the chronicity of NHPH infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12814","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T06:33:51Z","timestamp":1620801231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute gastric mucosal lesions caused by acute infection of non\u2010<i>Helicobacter<\/i><i>pylori<\/i><i>Helicobacter<\/i>: a case report"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1286-1038","authenticated-orcid":false,"given":"Toshihisa","family":"Tsukadaira","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kenwakai Hospital  Iida Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kenwakai Hospital  Iida Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Sciences Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kenwakai Hospital  Iida Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kenwakai Hospital  Iida Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-9586","authenticated-orcid":false,"given":"Himiko","family":"Kodaira","sequence":"additional","affiliation":[{"name":"Department of Pathology Kenwakai Hospital  Iida Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-5474","authenticated-orcid":false,"given":"Takehisa","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences Gumma University Graduate School of Health Sciences  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-2562","authenticated-orcid":false,"given":"Tatsuya","family":"Negishi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Showa Inan General Hospital  Komagane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63117-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12449"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01654729"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.6.2381-2382.2000"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-008-0313-x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00801.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12700"},{"key":"e_1_2_6_9_1","first-page":"48","article-title":"Prevalence and clinicopathological characteristics of patients with gastric disease infected with gastric Non\u2010Helicobacter pylori Helicobacter","volume":"21","author":"Tsukadaira 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