{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:46:41Z","timestamp":1787503601123,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) eradication reduces gastric cancer risk. Since 2013, a population\u2010wide\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication strategy for patients with chronic gastritis has begun to prevent gastric cancer in Japan. The aim of this study was to evaluate the economic and health effects of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication strategy in national gastric cancer prevention program.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We developed a cohort state\u2010transition model for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication and no eradication over a lifetime horizon from a healthcare payer perspective, and performed one\u2010way and probabilistic sensitivity analyses. We targeted a hypothetical cohort of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010positive patients aged 20, 30, 40, 50, 60, 70, and 80. The main outcomes were costs, quality\u2010adjusted life\u2010years (QALYs), life expectancy life\u2010years (LYs), incremental cost\u2010effectiveness ratios, gastric cancer cases, and deaths from gastric cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication was more effective and cost\u2010saving for all age groups than no eradication. Sensitivity analyses showed strong robustness of the results. From 2013\u20102019 for 8.50 million patients,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication saved US$3.75 billion, increased 11.11 million QALYs and 0.45 million LYs, and prevented 284,188 cases and 65,060 deaths. For 35.59 million patients without eradication,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication has the potential to save US$14.82 billion, increase 43.10 million QALYs and 1.66 million LYs, and prevent 1,084,532 cases and 250,256 deaths.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      National policy using population\u2010wide\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication to prevent gastric cancer has significant cost savings and health impacts for young\u2010, middle\u2010, and old\u2010aged individuals in Japan. The findings strongly support the promotion of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication strategy for all age groups in high\u2010incidence countries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12837","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:30:10Z","timestamp":1626654610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Economic and health impacts of introducing\n                    <i>Helicobacter pylori<\/i>\n                    eradication strategy into national gastric cancer policy in Japan: A cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5200-4300","authenticated-orcid":false,"given":"Akiko","family":"Kowada","sequence":"first","affiliation":[{"name":"Department of Occupational Health Kitasato University Graduate School of Medical Sciences Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido Ishikari gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00889.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i20.2618"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487795"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506120"},{"key":"e_1_2_8_7_1","unstructured":"World Cancer Research Fund International Stomach cancer statics. 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