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Therefore, new and effective therapies are needed for<jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic>infection. We conducted a systematic review and meta\u2010analysis to assess the efficacy and safety of semisynthetic tetracycline regimens in<jats:italic>H<\/jats:italic>.<jats:italic>\u00a0pylori<\/jats:italic>treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, and the Cochrane library were searched. The outcome indicators were the eradication rate, risk ratio (RR, ie, the risk of the semisynthetic tetracycline regimen relative to the control), and 95% confidence interval (95% CI). Controls were patients undergoing any other treatment without semisynthetic tetracycline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three studies with 5240 participants were included. The eradication rates of triple regimens with semisynthetic tetracyclines in most studies were less than 70% in both the intention\u2010to\u2010treat (ITT) and the per\u2010protocol (PP) analyses. The pooled eradication rates of quadruple therapies with doxycycline and controls were 95% and 84% in the PP analyses, respectively. The pooled RR associated with efficacy in the quadruple therapy with doxycycline group compared with the control group was 1.12 (95% CI: 1.04\u20131.20) in the PP analysis. The pooled RR of side effects in the quadruple therapy with doxycycline group compared with the control group was 1.01 (95% CI: 0.65\u20131.55).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Seven\u2010day and ten\u2010day quadruple therapy with doxycycline might be an optional first\u2010line therapy. The safety of regimens containing semisynthetic tetracyclines was relatively satisfactory. However, the triple regimen is not recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12839","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T09:39:07Z","timestamp":1627465147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Doxycycline and minocycline in<i>Helicobacter pylori<\/i>treatment: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Jixiang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Nanchang University Nanchang China"},{"name":"Queen Mary College of Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2507-5546","authenticated-orcid":false,"given":"Yunzhi","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First 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