{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:36:04Z","timestamp":1783434964712,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vonoprazan\u2010based <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori<\/jats:italic>) treatment is highly effective in eradicating the target bacteria; however, its post\u20101\u2010year impact on gut microbiota is unknown. This study evaluated the impact of vonoprazan\u2010based <jats:italic>H.\u00a0pylori<\/jats:italic> therapy on gut microbiota 1\u2010year post\u2010therapy and investigated the relationship between body weight changes and post\u2010therapy gut microbiota perturbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Between March and May 2019, 43 patients with <jats:italic>H.\u00a0pylori<\/jats:italic> infections received either vonoprazan\/amoxicillin (VA) or vonoprazan\/amoxicillin\/clarithromycin (VAC) therapy. Fecal samples were collected prior to treatment and 1\u00a0year after treatment. The alpha and beta diversities and the bacterial taxa composition ratios were determined using polymerase chain reaction amplification of the V3\u2013V4 region of the 16S ribosomal RNA gene. The correlation between body weight changes and relative abundances of genera post\u2010therapy was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 43 patients, 18 received VA therapy and 21 received VAC therapy. One year after treatment, the alpha diversity was significantly higher in both the treatment groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, using observed operational taxonomic units and Chao1 index), and beta diversity was significantly different in both the groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, using unweighted UniFrac distance) compared with baseline findings. Significant positive correlations were found between body weight changes and the relative abundances of <jats:italic>Coprococcus<\/jats:italic> spp. (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.037) and <jats:italic>Odoribacter<\/jats:italic> spp. (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.022) post\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vonoprazan\u2010based <jats:italic>H.\u00a0pylori<\/jats:italic> therapies are associated with long\u2010term impacts on gut microbiota, including effects on bacterial species richness, and potentially affect metabolism by altering the microbiota. Trial registration number: UMIN000040025.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12851","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T08:35:11Z","timestamp":1630917311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long term impact of vonoprazan\u2010based <i>Helicobacter pylori<\/i> treatment on gut microbiota and its relation to post\u2010treatment body weight changes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-1409","authenticated-orcid":false,"given":"Sho","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine Tokyo Japan"},{"name":"Department of Gastroenterology Yuri Kumiai General Hospital Akita 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