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The present study evaluated the association between serum antibodies against 15 different<jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>proteins measured by using multiplex serology\u00a0assay and GC risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed databases, Embase, Web of Science, and Cochrane Library for relevant articles. A meta\u2010analysis was used to pool studies and to estimate odds ratios (ORs) with 95% confidence intervals (95%CIs) of different<jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>antigens associated with GC risk. Heterogeneity was investigated using Cochran's<jats:italic>Q<\/jats:italic>test and<jats:italic>I<\/jats:italic>\u2010squared statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies were identified, with a total of 3209 GC cases and 6964 controls. Five<jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>virulence factors were significantly associated with non\u2010cardia GC risk at<jats:italic>p<\/jats:italic>\u2010value &lt;0.0033 including: CagA (OR\u00a0=\u00a03.22, 95%CI: 2.10\u20134.94), HP0305 (OR\u00a0=\u00a01.72, 95%CI: 1.32\u20132.25), HyuA (OR\u00a0=\u00a01.42, 95%CI: 1.13\u20131.79), Omp (OR\u00a0=\u00a01.83, 95%CI: 1.30\u20132.58), and VacA (OR\u00a0=\u00a02.05, 95%CI: 1.67\u20132.52). However, none of the 15 antigens was associated with cardia GC risk. In subgroup analysis by ethnicity, we identified 7 antigens associated with the risk of non\u2010cardia GC among East Asian while only two antigens were identified in European population. Nevertheless, CagA and GroEL showed a stronger association in Caucasian (CagA OR\u00a0=\u00a05.83, 95%CI: 3.31\u201310.26; GroEL OR\u00a0=\u00a03.66, 95%CI: 1.58\u20138.50) compared with East Asian (CagA OR\u00a0=\u00a02.20, 95% CI: 1.85\u20132.61; GroEL OR\u00a0=\u00a01.47, 95%CI: 1.29\u20131.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study determined that<jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>infection increases the risk of non\u2010cardia GC with differential effects by its virulence factors and with different patterns among East Asian and European populations. These results advance the understanding of the effect of<jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic>on GC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12881","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T07:16:44Z","timestamp":1645773404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between<i>Helicobacter pylori<\/i>antibodies determined by multiplex serology and gastric cancer risk: A meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Fadoua","family":"El Hafa","sequence":"first","affiliation":[{"name":"Department of Epidemiology Center for Global Health School of Public Health Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Global Health School of Public Health Nanjing Medical University Nanjing China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health Nanjing Medical University Nanjing China"},{"name":"Public Health Institute of Gusu School The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie Mbuhnwi","family":"Ndifor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Global Health School of Public Health Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Global Health School of Public Health Nanjing Medical University Nanjing China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health Nanjing Medical University Nanjing China"},{"name":"Public Health Institute of Gusu School The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou China"},{"name":"Jiangsu Key Laboratory of Molecular and Translational Cancer Research Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. 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