{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:25:50Z","timestamp":1787966750419,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000531"],"award-info":[{"award-number":["82000531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170580"],"award-info":[{"award-number":["82170580"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vonoprazan\u2010amoxicillin (VA) dual therapy has been shown to achieve acceptable cure rates for treatment of <jats:italic>Helicobacter pylori<\/jats:italic>(<jats:italic>H. pylori<\/jats:italic>) in Japan. Its effectiveness in other regions is unknown. We aimed to explore the efficacy of VA dual therapy as first\u2010line treatment for <jats:italic>H. pylori<\/jats:italic>infection in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single center, prospective, randomized clinical pilot study conducted in China. Treatment naive <jats:italic>H. pylori<\/jats:italic>infected patients were randomized to receive either low\u2010 or high\u2010dose amoxicillin\u2010vonoprazan consisting of amoxicillin 1\u2009g either b.i.d. or t.i.d plus VPZ 20\u2009mg b.i.d for 7 or 10\u2009days. <jats:sup>13<\/jats:sup>C\u2010urea breath tests were used to access the cure rate at least 4\u2009weeks after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and twenty\u2010three patients were assessed, and 119 subjects were randomized. The eradication rates of b.i.d. amoxicillin for 7 and 10\u2009days, t.i.d. amoxicillin for 7 and 10\u2009days were 66.7% (16\/24), 89.2% (33\/37), 81.0% (17\/21), and 81.1% (30\/37) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.191) by intention\u2010to\u2010treat analysis, respectively, and 72.7% (16\/22), 89.2% (33\/37), 81.0% (17\/21), and 81.1% (30\/37) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.454) by per\u2010protocol analysis, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neither 7\u2010 or 10\u2010day VA dual therapy with b.i.d. or t.i.d. amoxicillin provides satisfied efficacy as the first\u2010line treatment for <jats:italic>H. pylori<\/jats:italic>infection in China. Further optimization is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12896","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T07:43:49Z","timestamp":1650872629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Optimization of vonoprazan\u2010amoxicillin dual therapy for eradicating <i>Helicobacter pylori<\/i>infection in China: A prospective, randomized clinical pilot study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-7612","authenticated-orcid":false,"given":"Yi","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"JiangXi Clinical Research Center for Gastroenterology  Nanchang 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