{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:14:14Z","timestamp":1780506854035,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infection is strongly associated with chronic gastritis and is probably the main course of chronic inflammation in the gastric mucosa. Gradually, <jats:italic>H.\u00a0pylori<\/jats:italic> gastritis will result in gastric atrophy and intestinal metaplasia. Identifying the relationship between intensity of colonization and activity of gastritis helps the clinician in more effective treatment and post\u2010treatment follow\u2010ups. The aim of our work was to analyze the relationship between the density of <jats:italic>H.\u00a0pylori<\/jats:italic> colonization of the gastric mucosa and the severity of histological parameters of gastritis (inflammation activity, gastric atrophy, and intestinal metaplasia). This was a prospective monocentric study conducted from January 2020 to December 2020, collecting patients naive to any anti\u2010<jats:italic>H.\u00a0pylori<\/jats:italic> treatment and having a chronic <jats:italic>H.\u00a0pylori<\/jats:italic> infection documented by histological examination. Epidemiological, endoscopic, and anathomopathological data were collected. Ninety\u2010seven patients with a mean age of 42.6\u2009years [18\u201365\u2009years] and a sex ratio of M\/F\u00a0=\u00a00.64 were included. The density of <jats:italic>H.\u00a0pylori<\/jats:italic> colonization was mild (+) in 43.3% of patients, moderate (++) in 47.4% of patients, and significant (+++) in 9.3% of patients. Nearly, ten per cent of patients had no gastritis, 33% had mild gastritis, 50.5% had moderate gastritis, and 6.2% had severe gastritis. Gastric atrophy and intestinal metaplasia were found in 44.3% and 10.3% of our population, respectively. Patients with mild <jats:italic>H.\u00a0pylori<\/jats:italic> colonization rates had the highest level of mild activity (59.5%). There was a statistically significant association between the severity of <jats:italic>H.\u00a0pylori<\/jats:italic> infection and gastritis activity (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Gastric atrophy was significantly associated with the intensity of <jats:italic>H.\u00a0pylori<\/jats:italic> colonization (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.049). No significant relationship was found between the intensity of colonization and metaplasia (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.08). Our study shows that there is a statistically significant association between the density of <jats:italic>H.\u00a0pylori<\/jats:italic> and histopathological findings including gastritis activity and intestinal atrophy.<\/jats:p>","DOI":"10.1111\/hel.12910","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:49:01Z","timestamp":1655135341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Correlation between the intensity of <i>Helicobacter pylori<\/i> colonization and severity of gastritis: Results of a prospective study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-1990","authenticated-orcid":false,"given":"Salma","family":"Souissi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Mahmoud Matri Hospital  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrine","family":"Makni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mahmoud Matri Hospital  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Belhadj Ammar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mahmoud Matri Hospital  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Bousnina","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mahmoud Matri Hospital  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Kallel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Mahmoud Matri Hospital  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1998.00004.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1019918"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v4.i1.5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0509-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.03.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2016.23.28.8839"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8320496"},{"key":"e_1_2_9_11_1","unstructured":"Nouvelles recommandations sur la prise en charge des patients infect\u00e9s parHelicobacter pylori[Internet]. FMC\u2010HGE. [cit\u00e9 16 nov 2020]. Disponible sur:https:\/\/www.fmcgastro.org\/textes\u2010postus\/postu\u20102016\u2010paris\/nouvelles\u2010recommandations\u2010sur\u2010la\u2010prise\u2010en\u2010charge\u2010des\u2010patients\u2010infectes\u2010par\u2010helicobacter\u2010pylori\/"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1773-035X(14)72313-5"},{"key":"e_1_2_9_13_1","unstructured":"FarajPA BerbichPA LazrakPB ChkiliPT AlaouiPMT BelmahiPA.Universite Mohammed V de Rabat Faculte de Medecine et de Pharmacie \u2013 Rabat. 153."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.19082\/7279"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.23937\/2643-4466\/1710019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.1995.10.2.125"},{"issue":"3","key":"e_1_2_9_17_1","first-page":"325","article-title":"Correlation of HP density with grading of chronic gastritis","volume":"44","author":"Choudhary CK","year":"2001","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_9_18_1","unstructured":"DoffouSA BangouraAD Kouam\u00e9GD et al.Correlation between the intensity of Helicobacter pylori infection and the severity of gastric atrophy and gastric intestinal metaplasia according to the Sydney system. 7."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20150607"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.12910","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:36:37Z","timestamp":1692876997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,13]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/hel.12910"],"URL":"https:\/\/doi.org\/10.1111\/hel.12910","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,13]]},"assertion":[{"value":"2022-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12910"}}