{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:11:07Z","timestamp":1781277067313,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and its related diseases are substantial public health burden for highly infected areas. Recently, a novel family\u2010based <jats:italic>H. pylori<\/jats:italic> infection control and management (FBCM) strategy is introduced for <jats:italic>H. pylori<\/jats:italic> infection prevention and control. However, its cost\u2010effectiveness has not been evaluated. We conducted this health economic evaluation to investigate the cost\u2010effectiveness of FBCM, screen\u2010and\u2010treat, and no\u2010screen strategies in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Cost\u2010effectiveness analysis was performed using decision tree and Markov model. Parameters required for the model were from published literatures and public databases, including health state utility, screening characteristics, treatment effectiveness, and medical costs for the three strategies. Outcomes were cost, quality\u2010adjusted life year (QALY), incremental cost\u2010effectiveness ratio (ICER). Uncertainty analysis was performed to verify the robustness of this model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To prevent gastric cancer in a cohort of 1 million asymptomatic Chinese families, FBCM and screen\u2010and\u2010treat strategies prevented 1010 and 1201 new gastric cancer cases, reduced 2809 and 3339 gastric cancer\u2010related death, and saved 956,971 and 1,137,549 QALYs, respectively, when compared with no\u2010screen strategy. Cost\u2010effectiveness analysis showed that FBCM strategy cost $9.18\/QALY, and screen\u2010and\u2010treat strategy cost $12.08\/QALY for gastric cancer prevention when compared with no\u2010screen strategy. One\u2010way sensitivity analysis revealed that screening from younger age by both strategies are more cost\u2010effective. When compared with FBCM strategy, screen\u2010and\u2010treat strategy saved 5.98% gastric cancer cases and 5.78% of gastric cancer deaths, but costed $9348 to reduce a gastric cancer case. Results are not sensitive to any variables, and probabilistic sensitivity analysis confirmed robustness of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both FBCM and screen\u2010and\u2010treat strategies are cost\u2010effective for gastric cancer prevention compared with no\u2010screen strategy. Since FBCM is more practical and convenient, it may be an efficient and excellent cost\u2010effective strategy for gastric cancer prevention in <jats:italic>H. pylori<\/jats:italic> and gastric cancer prevalent areas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12911","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T06:12:44Z","timestamp":1655359964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Both family\u2010based <i>Helicobacter pylori<\/i> infection control and management strategy and screen\u2010and\u2010treat strategy are cost\u2010effective for gastric cancer prevention"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1172-527X","authenticated-orcid":false,"given":"Jing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou University, and Henan 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