{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:17:14Z","timestamp":1789391834194,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The currently recommended quadruple regimens as rescue therapy on\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection were not as effective as being supposed, especially in those who had failed two or more times. Dual regimen composed of vonoprazan (a potassium\u2010competitive acid blocker) and amoxicillin might be an option since it's effective in eradication therapy as first\u2010line treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      As a real\u2010world retrospective study, data were collected to evaluate the efficacy and safety of vonoprazan and amoxicillin dual regimen as rescue therapy in\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      positive patients who had failed one or more times in their previous treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From May 2020 to June 2021, the clinical data of patients who had failed in\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection treatment were collected in GI department of Peking University First Hospital, Beijing, China. Patients were given vonoprazan 20\u2009mg or 40\u2009mg per day and amoxicillin 3000\u2009mg per day (VA dual therapy) for 14\u2009days as rescue treatment.\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      status was evaluated by\n                      <jats:sup>13<\/jats:sup>\n                      C\u2010urease breath test 6\u2009weeks after treatment. All adverse effects during treatment were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 186 patients were enrolled, including 67 males and 119 females. All of them had failed for 1\u2009~\u20097 times in their previous treatment. Successful eradication was achieved in 172 patients (92.5%, 172\/186). The adverse effects (referring to skin rash, abdominal pain, diarrhea, and headache), mainly mild and did not cause quit of treatment, occurred in 14 patients (7.5%, 14\/186) and all symptoms relieved spontaneously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Dual regimen composed of vonoprazan and amoxicillin for 14\u2009days was effective and safe as rescue therapy in\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection treatment. It could be chosen as a \u201csimplified rescue therapy\u201d with relatively high eradication rate no matter how many times the patients had failed and what regimens they had used previously.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12918","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T13:35:03Z","timestamp":1658756103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Eradication rate and safety of a \u201csimplified rescue therapy\u201d: 14\u2010day vonoprazan and amoxicillin dual regimen as rescue therapy on treatment of\n                    <i>Helicobacter pylori<\/i>\n                    infection previously failed in eradication: A real\u2010world, retrospective clinical study in China"],"prefix":"10.1111","volume":"27","author":[{"given":"Wen","family":"Gao","sequence":"first","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guigen","family":"Teng","sequence":"additional","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Wang","sequence":"additional","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0876-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00788.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12804"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12717"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12816"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.10.036"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12554"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.08.021"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00856.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i40.4548"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.059"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501327211014087"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12640"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319954"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30219-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12692"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091311"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.01559.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12432"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.55.3.211"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.18"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12860"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502287"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2521-18"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15252"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i16.1907"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.007"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.12918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T01:52:55Z","timestamp":1692755575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/hel.12918"],"URL":"https:\/\/doi.org\/10.1111\/hel.12918","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]},"assertion":[{"value":"2022-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12918"}}