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However, some cancers still do not respond to PD\u20101\/PD\u2010L1 blockade therapy effectively.<jats:italic>Helicobacter pylori<\/jats:italic>infection might affect the curative effect of immunotherapy while it is rarely reported. We aimed to visualize the research hotspots and trends of<jats:italic>H.\u00a0pylori<\/jats:italic>and immunotherapy using a bibliometric analysis to help understand the future development of basic and clinical research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The relevant publications on<jats:italic>H.\u00a0pylori<\/jats:italic>and immunotherapy were searched on April 20, 2022, in the Web of Science Core Collection Database (WOSCC). The document types were limited to articles and reviews. The VOSviewer 1.6.16 software was used to assess the co\u2010authorship, co\u2010occurrence, citation of countries, institutions, authors, journals, and hotspot keywords. The research status and trend change of<jats:italic>H.\u00a0pylori<\/jats:italic>and immunotherapy were analyzed by bibliometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 95 studies authored by 561 researchers were eventually included in this study. The majority of the retrieved studies were 55 (58%) original research articles. China conducted the greatest number of studies, followed by USA and Italy. The related topics included the following three aspects: the relationship between microorganisms and cancer, the relationship between gastric cancer and immunity, and the relationship between<jats:italic>H.\u00a0pylori<\/jats:italic>and immunotherapy, including purified\/cloned components of<jats:italic>H.\u00a0pylori<\/jats:italic>acting as efficient adjuvant to boost tumor responses and<jats:italic>H.\u00a0pylori<\/jats:italic>infection which modulate host immune responses and impact on the efficacy of antitumor immunity initiated by immune checkpoint inhibitors. The timing diagram revealed that the current research hotspots focused on effects of microorganisms on immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effect of<jats:italic>H.\u00a0pylori<\/jats:italic>on cancer immunotherapy is getting more and more attention in these years. It still remains uncertain, and more studies are needed in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12925","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T08:45:41Z","timestamp":1661762741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of<i>Helicobacter pylori<\/i>on immunotherapy is gaining more attention"],"prefix":"10.1111","volume":"27","author":[{"given":"Yanyan","family":"Shi","sequence":"first","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital Beijing 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