{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:36:17Z","timestamp":1770384977391,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170562"],"award-info":[{"award-number":["82170562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to general unavailability and common side effects of tetracycline, the clinical application of bismuth quadruple therapy (BQT) is greatly limited. Whether amoxicillin can replace tetracycline in BQT remains unknown. This study aimed to compare the eradication rate, safety and compliance between amoxicillin\u2010containing and tetracycline\u2010containing BQT as a first\u2010line regimen for <jats:italic>Helicobacter pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized trial was conducted on 404 na\u00efve patients for <jats:italic>H. pylori<\/jats:italic> eradication. The participants were randomly assigned to 14\u2010day amoxicillin\u2010containing (bismuth potassium citrate 110\u2009mg four times\/day, esomeprazole 20\u2009mg twice daily, metronidazole 400\u2009mg four times\/day and amoxicillin 500\u2009mg four times\/day) and tetracycline\u2010containing (tetracycline 500\u2009mg four times\/day and the other three drugs used as above) BQT. Safety and compliance were assessed within 3\u2009days after eradication. Urea breath test was performed 4\u20138\u2009weeks after eradication to evaluate outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As for the eradication rates of amoxicillin\u2010containing and tetracycline\u2010containing BQT, the results of both intention\u2010to\u2010treat and per\u2010protocol analyses showed that the difference rate of the lower limit of 95% confidence interval was above \u221210.0% (intention\u2010to\u2010treat analysis: 81.7% vs. 83.2%, with a rate difference of \u22121.5% [\u22126.3% to 9.3%]; per\u2010protocol analysis: 89.0% vs. 91.6%, \u22122.6% [\u22124.1% to 9.3%]). The incidence of adverse events in amoxicillin\u2010containing BQT was significantly lower than tetracycline\u2010containing BQT (29.5% vs. 39.7%). Both groups achieved relatively good compliance (92.0% vs. 89.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The eradication efficacy of amoxicillin\u2010containing BQT was non\u2010inferior to tetracycline\u2010containing BQT as a first\u2010line regimen for <jats:italic>H. pylori<\/jats:italic> eradication with better safety and similar compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12935","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T14:39:54Z","timestamp":1668436794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bismuth, esomeprazole, metronidazole and amoxicillin or tetracycline as a first\u2010line regimen for <i>Helicobacter pylori<\/i> eradication: A randomized controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Xue\u2010li","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao\u2010jun","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010ping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai\u2010ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010lu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing\u2010yu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-5522","authenticated-orcid":false,"given":"Li\u2010ya","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing 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