{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:04Z","timestamp":1791061324654,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although vonoprazan has been proven to be a highly potent drug for\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication, there have been no randomized trials comparing the effectiveness of regimens containing vonoprazan 20\u2009mg daily with alternative standard strategies. We aimed to assess the efficacy, tolerance, and cost\u2010effectiveness of quadruple therapy with vonoprazan 20\u2009mg daily as a first\u2010line therapy for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single\u2010center, open\u2010label, noninferiority, randomized controlled study in Zhejiang, China. Treatment\u2010naive\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010positive participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0234) were randomly assigned to three groups in a 1:1:1 ratio: vonoprazan 20\u2009mg daily with amoxicillin 1000\u2009mg, furazolidone 100\u2009mg and colloidal bismuth 200\u2009mg each given twice a day for 10\u2009days (V10) or 14\u2009days (V14), or esomeprazole 20\u2009mg with amoxicillin 1000\u2009mg, furazolidone 100\u2009mg and colloidal bismuth 200\u2009mg each given twice a day for 14\u2009days (E14). The primary endpoint was the eradication rates in each group. The secondary endpoints were the incidence of adverse events (AEs) and compliance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The eradication rates in the V10, V14 and E14 groups were 96.2% (89.2\u201399.2%), 94.9% (87.4\u201398.6%), and 93.6% (85.7\u201397.9%) in the intention\u2010to\u2010treat analysis, and 98.6% (92.7\u2013100.0%), 97.4% (90.8\u201399.7%), and 94.8% (87.2\u201398.6%) in the per\u2010protocol analysis, respectively. Quadruple therapy with vonoprazan 20\u2009mg daily was noninferior to the esomeprazole\u2010based regimen (Farrington and Manning test: margin 10%, significance level 2.5%). The adverse event rates were 12.8% versus 3.8% versus 6.4% in the V10, V14, and E14 groups, respectively. All regimens were well tolerated without significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.096). The cost\u2010effectiveness ratio was 1.32, 1.88, and 3.06 for the V10, V14, and E14 groups in the intention\u2010to\u2010treat analysis, respectively. (NCT04907747).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Vonoprazan (20\u2009mg daily) was as effective as esomeprazole (20\u2009mg twice a day) in quadruple therapies for the eradication of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      , was more economical, and was well tolerated. In addition, the 10\u2010day regimen of vonoprazan (20\u2009mg daily) was comparable to the 14\u2010day regimen.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12940","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T05:22:49Z","timestamp":1669958569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Quadruple therapy with vonoprazan 20\u2009mg daily as a first\u2010line treatment for\n                    <i>Helicobacter pylori<\/i>\n                    infection: A single\u2010center, open\u2010label, noninferiority, randomized controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Lifen","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 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