{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:35:36Z","timestamp":1791898536636,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection is a challenge for those who cannot use amoxicillin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the eradication rate and adverse effects of vonoprazan and tetracycline dual therapy as first\u2010line and rescue treatment regimens used in special populations with penicillin allergy or failed in previous amoxicillin\u2010containing therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Patients enrolled were those who were <jats:italic>H. pylori\u2010<\/jats:italic>positive with selected conditions: (1) allergic to penicillin, either na\u00efve to treatment or had failed before; or (2) failed in previous amoxicillin\u2010containing therapies. All enrolled patients accepted 14\u2010day vonoprazan and tetracycline dual therapy (VT dual therapy) as follows: vonoprazan (20\u2009mg b.i.d.) and tetracycline (500\u2009mg\u2009t.i.d. [body weight\u2009&lt;\u200970\u2009kg] or 500\u2009mg q.i.d. [body weight\u2009\u2265\u200970\u2009kg]). <jats:italic>H. pylori<\/jats:italic> status was evaluated by <jats:sup>13<\/jats:sup>C\u2010urease breath test 6\u2009weeks after treatment. All adverse effects were recorded. Some patients underwent bacterial culture and antibiotic susceptibility testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 62 patients were enrolled; 18 of them received VT dual therapy as first\u2010line treatment, 44 patients received VT dual therapy as rescue treatment. Overall, 58 of 62 patients achieved successful eradication (93.5%), while all involved (100%,18\/18) succeeded in the first\u2010line treatment group and 40 cases (90.9%, 40\/44) succeeded in the rescue treatment group. Sixty\u2010one (61\/62, 98.4%) patients completed the whole course of treatment. Adverse events occurred in 6 patients (6\/62, 9.7%), while one patient quit because of skin rash. All adverse effects were mild and relieved spontaneously after <jats:italic>H. pylori<\/jats:italic> treatment. Five patients achieved successful <jats:italic>H. pylori<\/jats:italic> culture, and all strains isolated were sensitive to tetracycline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the treatment of <jats:italic>H. pylori<\/jats:italic> infection in special populations with penicillin allergy or failed in previous amoxicillin\u2010containing therapies, a 14\u2010day vonoprazan and tetracycline dual therapy was effective and safe as first\u2010line and rescue treatment in our study. Further study is warranted to verify its efficacy, especially for those who cannot use amoxicillin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12947","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T05:28:16Z","timestamp":1674019696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A real\u2010world exploratory study on the feasibility of vonoprazan and tetracycline dual therapy for the treatment of <i>Helicobacter pylori<\/i> infection in special populations with penicillin allergy or failed in previous amoxicillin\u2010containing therapies"],"prefix":"10.1111","volume":"28","author":[{"given":"Wen","family":"Gao","sequence":"first","affiliation":[{"name":"GI Department Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"GI Department Peking 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