{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:00:30Z","timestamp":1792555230096,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the region\u2010specific relative risk of cardia\/non\u2010cardia gastric cancer (CGC\/NCGC) associated with <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori)<\/jats:italic> and quantify its contribution to gastric cancer burden using population attributable fraction (PAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Web of Science, and Cochrane Central databases were searched by two reviewers until April 20, 2022. The association between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and NCGC\/CGC was assessed using pooled odds ratios (ORs) with 95% confidence intervals (CIs). PAF was calculated using the formula of <jats:italic>H.\u00a0pylori<\/jats:italic> prevalence and the pooled OR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eight studies were included. A significant association was observed between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and NCGC in East Asia (OR, 4.36; 95% CI: 3.54\u20135.37) and the West (OR, 4.03; 95% CI: 2.59\u20136.27). Regarding CGC, a significant association was found only in East Asia (OR, 2.86; 95% CI: 2.26\u20133.63), not in the West (OR, 0.80; 95% CI: 0.61\u20131.05). For studies with a follow\u2010up time of \u226510\u2009years, pooled ORs for NCGC and CGC in East Asia were 5.58 (95% CI: 4.08\u20137.64) and 3.86 (95% CI: 2.69\u20135.55), respectively. Pooled OR for NCGC was 6.80 (95% CI: 3.78\u201312.25) in the West. PAFs showed that <jats:italic>H.\u00a0pylori<\/jats:italic> infection accounted for 71.2% of NCGC, 60.7% of CGC in East Asia, and 73.2% of NCGC in the West.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric cancer burden associated with <jats:italic>H.\u00a0pylori<\/jats:italic> infection exhibits important geographical differences. Prolonged follow\u2010up period could overcome the underestimation of the magnitude of the association between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and CGC\/NCGC. Customized strategies for <jats:italic>H.\u00a0pylori<\/jats:italic> screening and eradication should be implemented to prevent gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12950","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T16:03:14Z","timestamp":1673884994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Cardia and non\u2010cardia gastric cancer risk associated with <i>Helicobacter pylori<\/i> in East Asia and the West: A systematic review, meta\u2010analysis, and estimation of population attributable fraction"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhongxue","family":"Han","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital, Cheeloo College of Medicine, Shandong University 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