{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:36:38Z","timestamp":1790876198482,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010dose dual therapy (HDDT) is an emerging and promising therapeutic regime for <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) eradication. However, the pharmacokinetics of the components of HDDT, amoxicillin and proton pump inhibitor, are likely to be affected by body size. In this study, we aimed to find out the impact of body size on the efficacy of HDDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected the medical data of 385 treatment\u2010naive patients infected with <jats:italic>H. pylori<\/jats:italic> who received HDDT (esomeprazole 20\u2009mg and amoxicillin 750\u2009mg four times daily) for 14\u2009days from July 2020 to December 2021. The associations among the eradication efficacy, adverse events, and variables (sex, age, height, body weight, body mass index (BMI), body surface area (BSA), smoking, drinking, etc.) were analyzed respectively in our study. Among these factors, continuous variables were classified into categorical variables using the cut\u2010off values which were calculated by receiver operating characteristic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The eradication rate of HDDT was 89.9%. There were 55 (14.3%) patients who occurred adverse events during the treatment. Patients with height &lt;170.5\u00a0cm, body weight &lt;60.5\u00a0kg, BMI &lt;20.55\u2009kg\/m<jats:sup>2<\/jats:sup>, BSA &lt;1.69\u2009m<jats:sup>2<\/jats:sup> had a higher eradication rate (92.1% vs. 84.0%, 93.1% vs. 86.8%, 96.0% vs. 87.8%, 93.4% vs. 84.8%, all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The multivariate analysis showed that BSA \u22651.69\u2009m<jats:sup>2<\/jats:sup> (OR 2.53, 95% CI: 1.28\u20134.99, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007) was the only independent predictor of eradication failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HDDT could achieve better eradication efficacy in patients with small BSA. Clinicians should be aware of the impact of BSA on the <jats:italic>H. pylori<\/jats:italic> eradication rate and pay more attention to patients with large BSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12953","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T06:27:18Z","timestamp":1675492038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of body size on efficacy of high\u2010dose dual therapy for <i>Helicobacter pylori<\/i> eradication"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-3297","authenticated-orcid":false,"given":"Jia\u2010Lun","family":"Guan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Na","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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