{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:15:35Z","timestamp":1792278935761,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication in penicillin\u2010allergic patients is challenging. The effective regimen is lacking in areas with high antibiotic resistance and tetracycline unavailable. Minocycline, cefuroxime, and full\u2010dose metronidazole are promising drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the eradication rate, safety, and compliance among three new bismuth quadruple therapies for first\u2010line <jats:italic>H. pylori<\/jats:italic> eradication in penicillin\u2010allergic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized trial was conducted on 450 naive patients with <jats:italic>H. pylori<\/jats:italic> infection and penicillin allergy. The 14\u2010day minocycline\u2010metronidazole\u2010containing (minocycline 100\u2009mg twice daily and metronidazole 400\u2009mg four times\/day), minocycline\u2010cefuroxime\u2010containing (minocycline 100\u2009mg twice daily and cefuroxime 500\u2009mg twice daily), and cefuroxime\u2010metronidazole\u2010containing (cefuroxime 500\u2009mg twice daily and metronidazole 400\u2009mg four times\/day) bismuth quadruple therapies were randomly assigned to the participants. Safety and compliance were assessed within 3\u2009days after eradication. Urea breath test was performed 4\u20138\u2009weeks after eradication to evaluate outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The differences of eradication rates in either intention\u2010to\u2010treat (84.0%, 82.7%, and 23 82.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.896) or per\u2010protocol (91.7%, 90.9%, and 88.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.599) analysis among minocycline\u2010metronidazole, minocycline\u2010cefuroxime, and cefuroxime\u2010metronidazole\u2010containing bismuth quadruple therapies were statistically insignificant. The incidence of adverse events (35.1%, 22.6%, and 28.9%) and compliance (90.5%, 91.8%, and 91.9%) were similar. Taste distortion, nausea, and anorexia were more common in metronidazole\u2010containing regimens, and dizziness was more common in minocycline\u2010containing regimens. The allergy was rare (~3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The efficacies of three bismuth quadruple therapies containing minocycline, cefuroxime, and full\u2010dose metronidazole (pairwise) for first\u2010line <jats:italic>H. pylori<\/jats:italic> eradication in penicillin\u2010allergic patients were similarly satisfactory with relatively good safety and compliance. The study was registered in the Chinese Clinical Trials Registration (ChiCTR1900023702).<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12956","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T11:52:14Z","timestamp":1675857134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["New regimens as first\u2010line eradication therapy for <i>Helicobacter pylori<\/i> infection in patients allergic to penicillin: A randomized controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojun","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2064-5522","authenticated-orcid":false,"given":"Liya","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-419X","authenticated-orcid":false,"given":"Zhiqiang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12686"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309900"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.05.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12334"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"49","article-title":"Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. 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