{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:07:50Z","timestamp":1774382870770,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent data on the prevalence of H. <jats:italic>pylori<\/jats:italic> infection in Jamaica are lacking. It is postulated that there has been a decline in the prevalence of H. <jats:italic>pylori<\/jats:italic> infection and its associated complications. We determined sociodemographic characteristics, prevalence of H. <jats:italic>pylori<\/jats:italic> infection and clinical outcomes among adults undergoing esophagogastroduodenoscopy (EGD) and histology at the University Hospital of the West Indies (UHWI) between May 2018 and December 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A cross\u2010sectional study of patients (\u226518\u2009years old), who underwent EGD and histological evaluation for <jats:italic>H. pylori<\/jats:italic> infection, was conducted. Associations of H. <jats:italic>pylori<\/jats:italic> positivity and gastric cancer with sociodemographic\/clinical variables and endoscopic findings were determined by stepwise logistic regression using backward selection. Unadjusted and adjusted odds ratios with related 95% confidence intervals (Cis) were calculated for H. <jats:italic>pylori<\/jats:italic> positivity and gastric cancer status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 323 participants (mean age 58.6\u00a0\u00b1\u200917.8\u2009years, 54.2% females). H. <jats:italic>pylori<\/jats:italic> prevalence was 22.2% (<jats:italic>n<\/jats:italic>\u00a0=\u200970 of 315), 5.6% had gastric neoplasia (GN), 15.5% gastric atrophy, 11.4% intestinal metaplasia and 3.7% dysplasia on histology. Mucositis (64.5%), gastric ulcer (14.9%), and duodenal ulcer (13.9%) were the most common endoscopic findings. Participants with peptic ulcer disease (PUD) (unOR\u00a0=\u00a04.0; <jats:italic>p<\/jats:italic>\u00a0=\u2009.017), gastric cancer (unOR\u00a0=\u00a09.5; <jats:italic>p<\/jats:italic>\u00a0=\u2009.003), gastric atrophy (unOR\u00a0=\u00a012.8; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), and intestinal metaplasia (unOR\u00a0=\u00a05.0; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) had a significantly higher odds of being H. <jats:italic>pylori<\/jats:italic> positive, but after multivariable analyses only gastric atrophy remained significant (aOR\u00a0=\u00a027.3; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Participants with mucositis had a significantly lower odds of gastric cancer (unOR 0.1; <jats:italic>p<\/jats:italic>\u00a0=\u2009.035) while participants with dysplasia had significantly higher odds (unOR 8.0; <jats:italic>p<\/jats:italic>\u00a0=\u2009.042), but these were no longer significant after multivariable analyses (aOR\u00a0=\u00a00.2; <jats:italic>p<\/jats:italic>\u00a0=\u2009.156 and aOR\u00a0=\u00a018.9; <jats:italic>p<\/jats:italic>\u00a0=\u2009.070, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histology based prevalence of H. <jats:italic>pylori<\/jats:italic> infection is lower than previously reported in Jamaica. Gastric atrophy is a significant predictor of H. <jats:italic>pylori<\/jats:italic> positivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12968","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T04:34:15Z","timestamp":1680842055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["H. <i>pylori<\/i> predictors and outcomes among adults undergoing upper endoscopy at a Jamaican teaching hospital: A cross\u2010sectional study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-3256","authenticated-orcid":false,"given":"Y. M.","family":"Dawkins","sequence":"first","affiliation":[{"name":"Department of Medicine University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1246-7348","authenticated-orcid":false,"given":"S.","family":"Rowe\u2010Gardener","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3084-7723","authenticated-orcid":false,"given":"N.","family":"Guthrie\u2010Dixon","sequence":"additional","affiliation":[{"name":"Caribbean Institute for Health Research University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-4915","authenticated-orcid":false,"given":"R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pathology University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1180-3231","authenticated-orcid":false,"given":"T.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5283-2659","authenticated-orcid":false,"given":"M. G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-4073","authenticated-orcid":false,"given":"C.","family":"Cunningham\u2010Myrie","sequence":"additional","affiliation":[{"name":"Department of Community Health &amp; Psychiatry University of the West Indies  Mona Jamaica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"14","article-title":"A review on Helicobacter pylori: its biology, complications and management","volume":"7","author":"Ashwini P","year":"2015","journal-title":"Int J Pharm Pharm Sci"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365310"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000121348"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2019_357"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.04.003"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"3","article-title":"Epidemiology of Helicobacter pylori infection in Barbados","volume":"46","author":"Edwards CN","year":"1997","journal-title":"West Indian Med J"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"309","article-title":"The prevalence of Helicobacter pylori infection in patients undergoing upper gastrointestinal endoscopy in The Turks and Caicos Islands","volume":"59","author":"Whittle D","year":"2010","journal-title":"West Indian Med J"},{"issue":"7","key":"e_1_2_9_9_1","first-page":"698","article-title":"Prevalence of Helicobacter pylori infection in children in The Bahamas","volume":"61","author":"Carter F","year":"2012","journal-title":"West Indian Med J"},{"issue":"3","key":"e_1_2_9_10_1","first-page":"84","article-title":"Helicobacter pylori in patients undergoing upper endoscopy in Jamaica","volume":"43","author":"Lee MG","year":"1994","journal-title":"The West Indian Med J"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-10"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90806-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases10030057"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb113444.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/954361"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_9_17_1","first-page":"1","article-title":"IARC working group on the evaluation of carcinogenic risks to humans","volume":"61","author":"Schistosomes, liver flukes and Helicobacter pylori","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0812-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i32.4629"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10018-1208"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.i18"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02213130"},{"issue":"8","key":"e_1_2_9_23_1","first-page":"58","article-title":"Non\u2010invasive tests for the diagnosis of Helicobacter pylori: state of the art","volume":"89","author":"Kayali S","year":"2018","journal-title":"Acta Biomed"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01213.x"},{"issue":"6","key":"e_1_2_9_25_1","first-page":"374","article-title":"Antibiotic sensitivity of Helicobacter pylori in Jamaica","volume":"53","author":"Lee M","year":"2004","journal-title":"West Indian Med J"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/258610"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/516067"},{"issue":"1","key":"e_1_2_9_29_1","first-page":"9","article-title":"Diagnosis of Helicobacter pylori using the rapid urease test","volume":"3","author":"Uotani T","year":"2015","journal-title":"Ann. 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