{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:37:00Z","timestamp":1792100220366,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Potassium\u2010competitive acid blockers (P\u2010CAB) are recommended for the treatment of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infections, but dual therapy of P\u2010CAB with amoxicillin has been poorly studied. The current study compared the efficacy, adverse reactions, compliance, and effects on gut microbiota of 14\u2010day vonoprazan\u2010amoxicillin (VA) dual therapy with esomeprazole, bismuth potassium citrate, amoxicillin, and metronidazole (EBAM) quadruple therapy in treatment\u2010naive patients with\n                      <jats:italic>H<\/jats:italic>\n                      .\u2009\n                      <jats:italic>pylori<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This was a multicenter, open\u2010label, randomized, and controlled, non\u2010inferiority study. Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009194) enrolled from six centers were randomly divided into either the VA or EBAM group.\n                      <jats:italic>H<\/jats:italic>\n                      .\u2009\n                      <jats:italic>pylori<\/jats:italic>\n                      eradication was determined using\n                      <jats:sup>13<\/jats:sup>\n                      C urea breath tests (UBT) 4\u20136\u2009weeks post\u2010treatment. Fecal samples were collected, and gut microbial populations were analyzed by 16S rDNA and metagenomic sequencing technology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eradication rates of\n                      <jats:italic>H<\/jats:italic>\n                      .\u2009\n                      <jats:italic>pylori<\/jats:italic>\n                      in the VA and EBAM groups were 88.7% and 91.8%, respectively, according to intention\u2010to\u2010treat (ITT) analysis; 95.6% and 96.7% with per\u2010protocol (PP) analysis; and 94.5% and 96.7% with modified ITT (mITT) analysis (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The incidence of adverse reactions in the VA group was significantly lower compared to the EBAM group, and compliance within both groups was good. There was no difference in \u03b1\u2010diversity or microbial composition in the VA and EBAM groups at one\u2010month post\u2010treatment compared to baseline, except for a markedly reduced abundance of\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      in the EBAM group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      VA therapy achieved excellent eradication rates with low adverse reactions, good compliance, and little impact on gut microbiota. VA therapy should be recommended as a first\u2010line treatment against\n                      <jats:italic>H<\/jats:italic>\n                      .\u2009\n                      <jats:italic>pylori<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.12970","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T18:57:55Z","timestamp":1683745075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Eradication rates of\n                    <i>Helicobacter pylori<\/i>\n                    in treatment\u2010naive patients following 14\u2010day vonoprazan\u2010amoxicillin dual therapy: A multicenter randomized controlled trial in China"],"prefix":"10.1111","volume":"28","author":[{"given":"Jie","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u2010yun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The 13th People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4883-8713","authenticated-orcid":false,"given":"De\u2010kui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010lin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Second People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Yongchuan Hospital Affiliated to Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wenzhou Central Hospital  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010ying","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-7910","authenticated-orcid":false,"given":"Chun\u2010Hui","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Daping Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_7_3_1","first-page":"429","article-title":"Helicobacter pylori infection","volume":"115","author":"Fischbach W","year":"2018","journal-title":"Deutsches Arzteblatt International"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.57"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00164-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325630"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i40.14973"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12052"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309900"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12242"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i32.11415"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000132"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz046"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06876.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199702000-00008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0220-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-013-0028-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00508.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505204"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13588"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311304"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502287"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319954"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12896"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.2008.S56"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01592.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322368"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.08.007"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90214-3"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.38"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199910000-00001"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00158.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310376"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky530"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ137"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12498"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.007"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.055"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502287"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01709-4"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T11:26:06Z","timestamp":1692271566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/hel.12970"],"URL":"https:\/\/doi.org\/10.1111\/hel.12970","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"2023-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12970"}}