{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:23:35Z","timestamp":1753878215835,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many studies in adults have suggested an association between <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and chronic immune thrombocytopenia (ITP). In adults with ITP and <jats:italic>H. pylori<\/jats:italic> infection, eradicating <jats:italic>H. pylori<\/jats:italic> is recommended as the first\u2010line therapy. However, the association between ITP and <jats:italic>H. pylori<\/jats:italic> in children remains controversial. Diagnosing thrombocytopenia in pregnant women is challenging but crucial because maternal ITP causes neonatal ITP through transplacental transfer of immunoglobulin G, also known as passive ITP. Herein, we report a case of neonatal passive ITP due to maternal <jats:italic>H. pylori<\/jats:italic>\u2010associated ITP. A boy was born at term with neonatal thrombocytopenia to a mother tentatively diagnosed with gestational thrombocytopenia. However, further examination suggested that maternal thrombocytopenia was associated with <jats:italic>H. pylori<\/jats:italic>, and neonatal thrombocytopenia was diagnosed as ITP due to maternal ITP. The newborn received intravenous immunoglobulin treatment, and the thrombocytopenia did not recur. The mother was examined using esophagogastroduodenoscopy, and her rapid urease test using gastric mucosa tissue samples was positive. Subsequently, she was diagnosed with <jats:italic>H. pylori<\/jats:italic> infection and received <jats:italic>H. pylori<\/jats:italic> eradication therapy, after which her platelet count remained normal. To our knowledge, this is the first reported case of neonatal passive ITP secondary to maternal <jats:italic>H. pylori<\/jats:italic>\u2010associated ITP. This case suggests that maternal <jats:italic>H. pylori<\/jats:italic> infection can lead to the production of platelet autoantibodies, which can destroy antibody\u2010sensitized platelets in the mother and neonate. To summarize, <jats:italic>H. pylori<\/jats:italic> infection can also cause ITP in children. Therefore, pregnant women diagnosed with <jats:italic>H. pylori<\/jats:italic>\u2010associated ITP should receive <jats:italic>H. pylori<\/jats:italic> eradication therapy to prevent their neonates from developing passive ITP.<\/jats:p>","DOI":"10.1111\/hel.12976","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T12:19:03Z","timestamp":1679573943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of neonatal thrombocytopenia due to maternal <i>Helicobacter pylori<\/i>\u2010associated immune thrombocytopenia"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-8258","authenticated-orcid":false,"given":"Naho","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-6504","authenticated-orcid":false,"given":"Tamaki","family":"Ikuse","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuki","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"},{"name":"Neonatal Center Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukika","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"e202","article-title":"Neonatal thrombocytopenia: a review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia","volume":"119","author":"Donato H","year":"2021","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199906000-00017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16252"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i3.714"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005348"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12597"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.04146"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60004-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm195"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.7.s1.7.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13341"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.397"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802897"},{"key":"e_1_2_8_15_1","first-page":"1046","article-title":"Attempt to improve the diagnosis of immune thrombocytopenia by combined use of two different platelet autoantibodies assays (PAIgG and MACE)","volume":"87","author":"Fabris F","year":"2002","journal-title":"Haematologica"},{"key":"e_1_2_8_16_1","first-page":"843","article-title":"Management of adult primary immune thrombocytopenia based on Japanese clinical guides","volume":"58","author":"Tomiyama Y","year":"2017","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_8_17_1","first-page":"428","article-title":"Assessment of intergroup practice guideline for management of childhood ITP","volume":"45","author":"Fujisawa K","year":"2004","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03327.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2011.110025"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.12976","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:49:06Z","timestamp":1692485346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/hel.12976"],"URL":"https:\/\/doi.org\/10.1111\/hel.12976","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"type":"print","value":"1083-4389"},{"type":"electronic","value":"1523-5378"}],"subject":[],"published":{"date-parts":[[2023,3,23]]},"assertion":[{"value":"2023-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12976"}}