{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:17:50Z","timestamp":1789186670546,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bismuth\u2010based quadruple therapy (BQT) is recommended as the first\u2010line empirical therapy for <jats:italic>Helicobacter pylori<\/jats:italic> eradication as it is not associated with resistance. However, few studies have investigated the use of potassium\u2010competitive acid blockers for BQT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the efficacy and safety profiles of tegoprazan\u2010based BQT (TBMT) versus lansoprazole\u2010based BQT (LBMT) for <jats:italic>H<\/jats:italic>.\u2009<jats:italic>pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients older than 18 with an <jats:italic>H<\/jats:italic>.\u2009<jats:italic>pylori<\/jats:italic> infection without a history of <jats:italic>H<\/jats:italic>.\u2009<jats:italic>pylori<\/jats:italic> eradication who visited four university\u2010affiliated hospitals between March 2020 and December 2021. <jats:italic>H<\/jats:italic>.\u2009<jats:italic>pylori<\/jats:italic> infection was diagnosed using a rapid urease test or Giemsa staining. Patients were randomly assigned to the TBMT or LBMT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>217 subjects were randomly allocated to receive either TBMT (<jats:italic>n<\/jats:italic>\u2009=\u2009108) or LBMT (<jats:italic>n<\/jats:italic>\u2009=\u2009109) therapy. Intention\u2010to\u2010treat (ITT) eradication rates of TBMT and LBMT were 80.0% and 77.4% (95% confidence interval [CI]: \u22128.4 to 13.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.0124), respectively. Corresponding modified ITT rates were 90.3% and 84.5% (95% CI: \u22123.6 to 15.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.0005), respectively. Per\u2010protocol (PP) eradication rates of TBMT and LBMT were 90.2% and 82.4% (95% CI: \u22122.5 to 18.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.0003), respectively. There was no significant difference in the rate of adverse events between the TBMT and LBMT groups (39.1% vs. 43.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.5211). TBMT showed higher eradication rates than that of LBMT in ITT, m\u2010ITT, and PP analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TBMT showed a noninferior eradication rate and similar adverse events to LBMT as a first\u2010line eradication regimen. Our results suggest that tegoprazan might be substituted for proton pump inhibitors in <jats:italic>H<\/jats:italic>.\u2009<jats:italic>pylori<\/jats:italic> eradication regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12977","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T11:44:21Z","timestamp":1682077461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Efficacy of tegoprazan\u2010based bismuth quadruple therapy compared with bismuth quadruple therapy for <i>Helicobacter pylori<\/i> infection: A randomized, double\u2010blind, active\u2010controlled study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-1012","authenticated-orcid":false,"given":"Joon Sung","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weonjin","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Inha University Hospital, Inha University School of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Won","family":"Chung","sequence":"additional","affiliation":[{"name":"Divison of Gastroenterology, Department of Internal Medicine Gachon University, Gil Medical Center  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12835"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.244202"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15438"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl220055"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i46.6790"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15273"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.857569"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0226-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.1.5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321372"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12392"},{"key":"e_1_2_6_17_1","first-page":"9","article-title":"Transitioning of Helicobacter pylori therapy from trial and error to antimicrobial stewardship","volume":"9","author":"Graham DY","year":"2020","journal-title":"Antibiotics 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