{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:55:36Z","timestamp":1788018936858,"version":"build-2784847793"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize the serum metabolism in patients with <jats:italic>Helicobacter pylori<\/jats:italic>\u2010positive and <jats:italic>H. pylori<\/jats:italic>\u2010negative gastritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data and serum gastric function parameters, PGI (pepsinogen I), PGII, PGR (PGI\/II), and G\u201017 (gastrin\u201017) of 117 patients with chronic gastritis were collected, including 57 <jats:italic>H. pylori<\/jats:italic> positive and 60 <jats:italic>H. pylori<\/jats:italic> negative subjects. Twenty cases in each group were randomly selected to collect intestinal mucosa specimens and serum samples. The gut microbiota profiles were generated by 16S rRNA gene sequencing, and the serum metabolites were analyzed by a targeted metabolomics approach based on liquid chromatography\u2013mass spectrometry (LC\u2013MS) technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altered expression of 20 metabolites, including isovaleric acid, was detected in patients with HPAG. Some taxa of <jats:italic>Bacteroides<\/jats:italic>, <jats:italic>Fusobacterium<\/jats:italic>, and <jats:italic>Prevotella<\/jats:italic> in the gut microbiota showed significant correlations with differentially expressed metabolites between <jats:italic>H. pylori<\/jats:italic> positive and <jats:italic>H. pylori<\/jats:italic> negative individuals. As a result, an <jats:italic>H. pylori<\/jats:italic>\u2010gut microbiota\u2010metabolism (HGM) axis was proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> infection may influence the progression of mucosal diseases and the emergence of other complications in the host by altering the gut microbiota, and thus affecting the host serum metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12984","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T05:20:47Z","timestamp":1682486447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic alterations in patients with <i>Helicobacter pylori<\/i>\u2010related gastritis: The <i>H. pylori<\/i>\u2010gut microbiota\u2010metabolism axis in progression of the chronic inflammation in the gastric 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