{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:28:13Z","timestamp":1788906493400,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Japan became the world's first country to cover <jats:italic>Helicobacter pylori<\/jats:italic> eradication for chronic gastritis under its National Health Insurance (NHI) system in February 2013. Thereafter, <jats:italic>H. pylori<\/jats:italic> eradication dramatically increased and gastric cancer deaths began to decrease in Japan. However, the details of gastric cancer deaths and its prevention in the very elderly have not been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the temporal trend of gastric cancer deaths referencing data from Ministry of Health, Labour and Welfare reports and \u201cCancer Statistics in Japan\u20132021\u201d and assessed the numbers of <jats:italic>H. pylori<\/jats:italic> test and gastric cancer screening using a national database and a report of cancer screening in Shimane Prefecture, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although gastric cancer deaths in total population have clearly decreased since 2013, those in people aged 80\u2009years and older are still increasing. People aged 80\u2009years and older represent 9% of the total population and accounted for half of all gastric cancer deaths in 2020. The numbers of <jats:italic>H. pylori<\/jats:italic> eradication and gastric cancer screening in people aged 80\u2009years and older were 25% and 25% of those in other generations, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In spite of a dramatic increase in <jats:italic>H. pylori<\/jats:italic> eradication and a clear decrease in gastric cancer deaths in Japan, gastric cancer deaths in people aged 80\u2009years and older are increasing. This might be due to fewer <jats:italic>H. pylori<\/jats:italic> eradication in the elderly than in other generations, indicating the difficulty of gastric cancer prevention in the very elderly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.12988","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:03:51Z","timestamp":1685361831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An increasing trend of gastric cancer deaths and inadequate preventive measures in elderly adults"],"prefix":"10.1111","volume":"28","author":[{"given":"Rumiko","family":"Matsushima","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouji","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido  Tobetsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Health Administration and Policy Tohoku University School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"Advanced Research Promotion Center Health Sciences University of Hokkaido  Tobetsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_8_2_1","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 61","first-page":"1","volume-title":"Schistosomes, Liver Flukes and Helicobacter pylori","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"1994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27965"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_8_5_1","unstructured":"8 IWGRV. Helicobacter pylori eradication as a strategy for preventing gastric cancer.http:\/\/www.iarc.fr\/en\/publications\/pdfs\u2010online\/wrk\/wrk8\/Helicobacter_pylori_Eradication.pdf."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn017"},{"key":"e_1_2_8_7_1","first-page":"138","article-title":"Evaluation of H. pylori eradication by electronic recept analysis in Japan","volume":"12","author":"Fujimori K","year":"2015","journal-title":"GI Forefront"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12415"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-015855"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14586"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.582239"},{"key":"e_1_2_8_12_1","first-page":"40","volume-title":"Cancer Statistics in Japan\u20102018","year":"2018"},{"key":"e_1_2_8_13_1","unstructured":"Results of a survey on the number of people who underwent cancer screening.2011\u20102019 (surveyed by the Cancer Control Promotion Office Health Promotion Division Shimane Prefecture). 4\u20105 Survey of Cancer Screening Implementation System Report Shimane Prefecture Office of Cancer Control Health and Welfare Department Shimane Prefecture."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyt163"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z"},{"key":"e_1_2_8_16_1","unstructured":"NDB Database (Ministry of Health Labour and Welfare website)http:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000139390.html."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2008.00454.x"},{"key":"e_1_2_8_18_1","first-page":"56","article-title":"Investigation of examination methods appropriate for cancer prevention based on analysis of gastrointestinal endoscopic cancer screening in the elderly and analysis of the results","volume":"43","author":"Nagata K","year":"2020","journal-title":"Daiwa Securities Health Foundation Research Achievement"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.12988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:26:56Z","timestamp":1692286016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.12988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/hel.12988"],"URL":"https:\/\/doi.org\/10.1111\/hel.12988","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]},"assertion":[{"value":"2023-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12988"}}