{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:22:52Z","timestamp":1786378972020,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.82072253"],"award-info":[{"award-number":["NO.82072253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2021jcyj\u2010msxmX0451"],"award-info":[{"award-number":["cstc2021jcyj\u2010msxmX0451"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>According to the Maastricht VI\/Florence consensus report, potassium\u2010competitive acid blockers (P\u2010CAB) may improve <jats:italic>Helicobacter pylori<\/jats:italic> eradication treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 213 <jats:italic>H. pylori<\/jats:italic> treatment\u2010naive patients aged between 18 and 70\u2009years were treated with two regimens. The two regimens are VDT: 20\u2009mg vonoprazan twice a day and 1\u2009g amoxicillin three times daily and EDT: 20\u2009mg esomeprazole four times a day and 750\u2009mg amoxicillin four times daily. <jats:sup>13<\/jats:sup>C\u2010urea breath tests were used to evaluate eradication rate 4\u20136\u2009weeks after treatment. Based on propensity score matching (PSM), this retrospective study analyzed the eradication rates, adverse events (AEs), compliance, and antibiotic resistance rates in VDT and EDT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On intention\u2010to\u2010treat (ITT) analysis, the eradication rate in VDT group (89.0%; 95% CI 81.7\u201396.3) was non\u2010inferior to that in EDT group (87.7%; 95% CI 80.1\u201395.3; <jats:italic>p<\/jats:italic>\u2009=\u20090.796). The corresponding per\u2010protocol (PP) eradication rates were 94.1% (95% CI 88.4\u201399.8) and 92.8% (95% CI 86.7\u201398.9; <jats:italic>p<\/jats:italic>\u2009=\u20091.000), respectively. There were no significant between\u2010group differences with respect to compliance or incidence of AEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The efficacy and safety of 14\u2010day VDT and EDT were comparable. Therefore, 14\u2010day VDT or EDT may be recommended for the first\u2010line treatment of <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13003","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T09:44:25Z","timestamp":1691660665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of vonoprazan\u2010based dual therapy and esomeprazole\u2010based dual therapy in eradicating primary <i>Helicobacter pylori<\/i> infection: A propensity score matching analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-0425","authenticated-orcid":false,"given":"Na\u2010Yun","family":"Su","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng\u2010Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-7910","authenticated-orcid":false,"given":"Chun\u2010Hui","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing Key Laboratory of Digestive Malignancies, Daping Hospital Army Medical University, Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","article-title":"Epidemiology of Helicobacter pylori infection","volume":"22","author":"Burucoa C","year":"2017","journal-title":"Helicobacter"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32404-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2662"},{"key":"e_1_2_8_7_1","article-title":"Chinese national clinical practice guideline on Helicobacter pylori eradication treatment","volume":"135","author":"Zhou L","year":"2022","journal-title":"Chin Med J 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