{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:38:19Z","timestamp":1774388299188,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Migraine is one of the most common neurological disorders that can severely overshadow people's quality of life, and <jats:italic>Helicobacter pylori<\/jats:italic> infection is a health problem in different societies. During the last two decades, many original studies have been conducted on the various aspects of the relationship between these two disorders; however, they have reported different and sometimes contradictory results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted based on the PRISMA protocol. We performed a comprehensive literature search in the online databases up to May 2023, and 22 studies that contained original data on the relationship between <jats:italic>H. pylori<\/jats:italic> infection and migraine headaches in adults were included. For performing the meta\u2010analysis, we calculated the odds ratios (OR) and 95% confidence intervals (CI), using a random\u2010effects model, and to determine the possible causes of heterogeneity, we conducted a subgroup meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall OR for the association of <jats:italic>H. pylori<\/jats:italic> infection and migraine headaches through 493,794 evaluated individuals was 2.80 [95% CI\u2009=\u20091.75\u20134.48; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200989.20, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01], which reveals a statistically significant association between these disorders. It was found that the studies that were conducted in Asian regions and the recently published ones have clearly shown a higher association between migraine and <jats:italic>H. pylori<\/jats:italic> infection. On the other hand, migraine patients who are infected with <jats:italic>H. pylori<\/jats:italic> have similar signs and symptoms as <jats:italic>H. pylori<\/jats:italic>\u2010negative migraineurs; meanwhile, the clinical trials conducted in this field strongly emphasize the benefits of eradicating <jats:italic>H. pylori<\/jats:italic> infection in migraine patients and have estimated its effectiveness in improving migraine headaches equivalent to current common migraine treatments. Furthermore, it was reported that white matter lesions were 2.5\u2010fold higher on brain MRI in patients with <jats:italic>H. pylori<\/jats:italic>\u2010positive migraine compared with <jats:italic>H. pylori<\/jats:italic>\u2010negative migraineurs; however, the evidence does not support the role of oxidative stress in patients suffering from <jats:italic>H. pylori<\/jats:italic> infection and migraine and refuses the role of Cag\u2010A\u2010positive strains of <jats:italic>H. pylori<\/jats:italic> in migraine headaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the currently available data, it seem reasonable that patients with a definite diagnosis of migraine who also suffer from gastrointestinal problems, undergo the <jats:italic>H. pylori<\/jats:italic> detection tests and if the evaluations are positive, <jats:italic>H. pylori<\/jats:italic> eradication treatment can be considered even before any migraine treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13010","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T08:33:46Z","timestamp":1690965226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of <i>Helicobacter pylori<\/i> with migraine headaches and the effects of this infection and its eradication on the migraine characteristics in adults: A comprehensive systematic review and <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"given":"Rashed","family":"Bawand","sequence":"first","affiliation":[{"name":"Department of General Medicine, School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-8558","authenticated-orcid":false,"given":"Masoud","family":"Ghiasian","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology, School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Samadyan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorush","family":"Qaderi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Pharmacy Hamadan University of Medical Sciences  Hamadan 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