{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T16:30:02Z","timestamp":1775493002036,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013064","name":"Key Research and Development Program of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vonoprazan is an emerging option for the treatment of <jats:italic>Helicobacter pylori<\/jats:italic> infection. We aimed to assess the research trends and hotspots of vonoprazan\u2010based therapy for <jats:italic>H. pylori<\/jats:italic> eradication through bibliometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Vonoprazan\u2010based studies for eradicating <jats:italic>H. pylori<\/jats:italic> published from 2015 to 2023 were extracted from the Web of Science using a combination of the search terms \u201c<jats:italic>H. pylori<\/jats:italic>\u201d and \u201cvonoprazan.\u201d Each study was weighted according to the number of included patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 65 studies were included. Japan was the most productive and cooperative country, accounting for 69.2% of publications. Vonoprazan in combination with amoxicillin and clarithromycin (41.8%) was most used for eradicating <jats:italic>H. pylori<\/jats:italic>, followed by vonoprazan in combination with amoxicillin (20.4%) and vonoprazan in combination with amoxicillin and metronidazole (19.4%). The eradication rates for first\u2010line vonoprazan\u2010based therapies by intention to treat were: dual therapy (82.9%, 95% CI: 77.7%\u201388.0%), triple (83.3%, 95% CI: 79.7%\u201386.8%) and quadruple therapy (91.5%, 95% CI: 85.5%\u201397.4%), and per protocol: dual therapy (86.1%, 95% CI: 81.5%\u201390.7%), triple (89.3%, 95% CI: 87.9%\u201390.6%) and quadruple therapy (94.0%, 95% CI: 88.6%\u201399.4%). Vonoprazan was superior to proton pump inhibitors in triple therapy regarding empirical therapy (RR\u2009=\u20091.18, 95% CI, 1.14\u20131.22, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and clarithromycin\u2010resistant group (RR\u2009=\u20091.71, 95% CI, 1.33\u20132.20, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but there is no significant difference between triple therapy and dual therapy (RR\u2009=\u20091.02, 95% CI, 0.98\u20131.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vonoprazan has been widely used for <jats:italic>H. pylori<\/jats:italic> eradication. Further studies are needed to optimize the best duration and dosage of vonoprazan\u2010based regimens in different regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13012","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T07:15:49Z","timestamp":1690614949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Research trends on vonoprazan\u2010based therapy for <i>Helicobacter pylori<\/i> eradication: A bibliometric analysis from 2015 to 2023"],"prefix":"10.1111","volume":"28","author":[{"given":"Ren\u2010Chun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Bin","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive 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