{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:33:20Z","timestamp":1792262000177,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The question of whether eradication of <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) can reverse gastric precancerous lesions, including intestinal metaplasia, remains uncertain, leading to ongoing debate. Therefore, a meta\u2010analysis was performed to evaluate the effect of Hp eradication on gastric precancerous lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>PubMed, Embase, Cochrane Library, Web of Science, Scopus database, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> were systematically searched from inception to April 2023 for studies that explored the impact of Hp eradication on gastric precancerous lesions. Risk ratios (RRs) and their 95% confidence intervals (95% CIs) were selected as the effect size. We used the random\u2010effects model to assess pooled data. We also performed quality assessments, subgroup analyses, and sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies were included. Compared with placebo, Hp eradication could significantly prevent the progression of gastric precancerous lesions (RR\u2009=\u20090.87, 95% CI: 0.81\u20130.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and reverse them (RR\u2009=\u20091.32, 95% CI: 1.17\u20131.50, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Then, specific precancerous lesions were further explored. The progression of intestinal metaplasia was significantly prevented by Hp eradication compared to placebo or no treatment (RR\u2009=\u20090.80, 95% CI: 0.69\u20130.94, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Moreover, compared with placebo or no treatment, Hp eradication also improved chronic atrophic gastritis (RR\u2009=\u20091.84, 95% CI: 1.30\u20132.61, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and intestinal metaplasia (RR\u2009=\u20091.41, 95% CI: 1.15\u20131.73, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). However, in terms of preventing dysplasia progression (RR\u2009=\u20090.86, 95% CI: 0.37\u20132.00) and improving dysplasia (RR\u2009=\u20090.89, 95% CI: 0.47\u20131.70), Hp eradication had no advantage compared to placebo or no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hp eradication therapy could prevent the progression of gastric precancerous lesions and reverse them. Notably, intestinal metaplasia can be reversed, but this may only be appropriate for patients with epigenetic alterations and milder lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13013","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:24:08Z","timestamp":1692696248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Effect of <i>Helicobacter pylori<\/i> eradication on gastric precancerous lesions: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-2137","authenticated-orcid":false,"given":"Fangyuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional and Western Medicine in Oncology The First Affiliated Hospital of Medical University of Anhui  Hefei 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