{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:17:10Z","timestamp":1789391830047,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Multidrug\u2010resistant\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      strains are emerging in Southeast Asia. This study evaluates the region's real\u2010world practice in\n                      <jats:italic>H<\/jats:italic>\n                      .\u2009\n                      <jats:italic>pylori<\/jats:italic>\n                      management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Physicians who managed\n                      <jats:italic>H<\/jats:italic>\n                      .\u2009\n                      <jats:italic>pylori<\/jats:italic>\n                      eradication in daily practice across 10 Southeast Asian countries were invited to participate in an online questionnaire, which included questions about the local availability of antimicrobial susceptibility tests (ASTs) and their preferred eradication regimens in real\u2010world practice. An empiric regimen was considered inappropriate if it did not follow the local guidelines\/consensus, particularly if it contained antibiotics with a high reported resistance rate or was recommended not to be empirically used worldwide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 564 valid responses, including 314 (55.7%) from gastroenterologists (GIs) and 250 (44.3%) from non\u2010GI physicians. ASTs were unavailable in 41.7%. In countries with low and intermediate clarithromycin resistance, the most common first\u2010line regimen was PAC (proton pump inhibitor [PPI], amoxicillin, clarithromycin) (72.7% and 73.2%, respectively). Regarding second\u2010line therapy, the most common regimen was bismuth\u2010based quadruple therapy, PBMT (PPI, bismuth, metronidazole, tetracycline) (50.0% and 59.8%, respectively), if other regimens were used as first\u2010line treatment. Concomitant therapy (PPI, amoxicillin, clarithromycin, metronidazole) (30.5% and 25.9%, respectively) and PAL (PPI, amoxicillin, levofloxacin) (22.7% and 27.7%, respectively) were favored if PBMT had been used as first\u2010line treatment. In countries with high clarithromycin resistance, the most common first\u2010line regimen was PBMT, but the utilization rate was only 57.7%. Alarmingly, PAC was prescribed in 27.8% of patients, ranking as the second most common regimen, and its prescription rate was higher in non\u2010GI physicians than GI physicians (40.1% vs. 16.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Choosing inappropriate regimens containing antibiotics with high resistance rates is not uncommon in Southeast Asia, especially among non\u2010GI physicians. In countries with high clarithromycin resistance, the PBMT regimen is underutilized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13018","type":"journal-article","created":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T11:09:20Z","timestamp":1693134560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Real\u2010world practice of\n                    <i>Helicobacter pylori<\/i>\n                    management: A survey among physicians in Southeast Asia"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-921X","authenticated-orcid":false,"given":"Duc Trong","family":"Quach","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"},{"name":"Department of Gastroenterology Nhan Dan Gia Dinh Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-9331","authenticated-orcid":false,"given":"Ratha\u2010korn","family":"Vilaichone","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medicine, and Center of Excellence in Digestive Diseases, Thammasat University, Thailand Science Research and Innovation Fundamental Fund Bualuang ASEAN Chair Professorship at Thammasat University  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-1764","authenticated-orcid":false,"given":"Mai Ngoc","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"},{"name":"Department of Gastroenterology Nhan Dan Gia Dinh Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-7717","authenticated-orcid":false,"given":"Yeong Yeh","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Malaysia"},{"name":"GI Function and Motility Unit Hospital Universiti Sains Malaysia  Kota Bharu Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8549","authenticated-orcid":false,"given":"Tiing Leong","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-6033","authenticated-orcid":false,"given":"Muhammad","family":"Miftahussurur","sequence":"additional","affiliation":[{"name":"Division of Gastroentero\u2010Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"},{"name":"Helicobacter Pylori and Microbiota Study Group, Institute of Tropical Disease Universitas Airlangga  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1521-0660","authenticated-orcid":false,"given":"Than Than","family":"Aye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Medicine 1  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-3502","authenticated-orcid":false,"given":"Dewi Norwani","family":"Basir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology RIPAS Hospital  Bandar Seri Begawan Brunei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ky","family":"Vutha","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology and Proctology Department Calmette Hospital  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sengdao","family":"Vannarath","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department Mahosot Hospital  Vientiane Laos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose D.","family":"Sollano","sequence":"additional","affiliation":[{"name":"University of Santo Tomas  Manila 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