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These shifts can be mediated through direct contact, toxic components, or indirect immune responses. Consequently, they influence various molecular metabolic events that impact nutritional status and iron absorption in the host. Unraveling the intricate and diverse molecular interaction links between <jats:italic>H.\u00a0pylori<\/jats:italic> and human metabolism modulation is essential for understanding pathogenesis mechanisms and developing targeted treatments for related diseases. However, significant challenges persist in comprehensively understanding the complex association networks among <jats:italic>H. pylori<\/jats:italic> itself, the infected host's status, the host microbiome, and the immune response. Previous metabolomics research has indicated that <jats:italic>H. pylori<\/jats:italic> infection and eradication may selectively shape the metabolite and microbial profiles of gastric lesions. Yet, it remains largely unknown how these diverse metabolic pathways, including isovaleric acid, cholesterol, fatty acids, and phospholipids, specifically modulate gastric carcinogenesis or affect the host's serum metabolism, consequently leading to the development of metabolic\u2010associated diseases. The direct contribution of <jats:italic>H. pylori<\/jats:italic> to metabolisms still lacks conclusive evidence. In this review, we summarize recent advances in clinical evidence highlighting associations between chronic <jats:italic>H. pylori<\/jats:italic> infection and metabolic diseases, as well as its potential molecular regulatory patterns.<\/jats:p>","DOI":"10.1111\/hel.13030","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:10:30Z","timestamp":1698106230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Interactions between <i>Helicobacter pylori<\/i> infection and host metabolic homeostasis: A comprehensive review"],"prefix":"10.1111","volume":"28","author":[{"given":"Junzhao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou PR 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