{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:39:11Z","timestamp":1791844751471,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2022SF135"],"award-info":[{"award-number":["2022SF135"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2021ZDLSF0206"],"award-info":[{"award-number":["2021ZDLSF0206"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Some gastrointestinal disorders may be associated with\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection, which not only affect maternal health, but may also lead to adverse pregnancy outcomes. We aim to explore the association between\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      and gastrointestinal disorders in pregnant women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In total, 503 patients were retrospectively analyzed and divided into the\n                      <jats:italic>H.\u2009pylori\u2010<\/jats:italic>\n                      uninfected group, the\n                      <jats:italic>H.\u2009pylori\u2010<\/jats:italic>\n                      infected group, or the\n                      <jats:italic>H.\u2009pylori\u2010<\/jats:italic>\n                      eradicated group. We analyzed the influence of\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      on gastrointestinal diseases during pregnancy among the groups, as well as the severity, symptoms, laboratory tests of the\n                      <jats:italic>H.\u2009pylori\u2010<\/jats:italic>\n                      related diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pregnant women with\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infection had higher risk of nausea and vomiting of pregnancy (NVP) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), severe NVP(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), hyperemesis gravidarum (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), hematemesis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), hyponatremia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), as well as functional dyspepsia symptoms including epigastric pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), bloating (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), and feeling full quickly in a meal (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) compared with those without\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infection. While the prevalence of NVP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), severe NVP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), epigastric pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037), and bloating (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) were lower in\n                      <jats:italic>H.\u2009pylori\u2010<\/jats:italic>\n                      eradicated pregnant women than in\n                      <jats:italic>H.\u2009pylori\u2010<\/jats:italic>\n                      infected women. In addition, pregnant women with\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infection had higher risk of spontaneous preterm birth than whom without\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection was associated with higher risks of NVP, severe NVP, hyperemesis gravidarum, functional dyspepsia, and spontaneous preterm birth in pregnant women.\n                    <\/jats:p>\n                  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