{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:36:58Z","timestamp":1792100218987,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent clinical trials have evaluated the efficacy of vonoprazan\u2010amoxicillin (VA) dual therapy as the first\u2010line treatment for <jats:italic>Helicobacter pylori<\/jats:italic> infection in different regions with inconsistent results reported. In this systematic review and meta\u2010analysis, we aimed to evaluate the efficacy of VA dual therapy compared to the currently recommended therapy for eradicating <jats:italic>H. pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A comprehensive search of the PubMed, Cochrane, and Embase databases was performed using the following search terms: (\u201c<jats:italic>Helicobacter<\/jats:italic>\u201d OR \u201c<jats:italic>H. pylori<\/jats:italic>\u201d OR \u201c<jats:italic>Hp<\/jats:italic>\u201d) AND (\u201cvonoprazan\u201d OR \u201cpotassium\u2010competitive acid blocker\u201d OR \u201cP\u2010CAB\u201d) AND (\u201camoxicillin\u201d OR \u201cpenicillin\u201d) AND (\u201cdual\u201d). The primary outcome was to evaluate the eradication rate according to intention\u2010to\u2010treat and per\u2010protocol analysis. The secondary outcomes were adverse events and compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies involving 4, 568 patients were included. The pooled eradication rate of VA dual therapy was 85.0% and 90.0% by intention\u2010to\u2010treat and per\u2010protocol analysis, respectively. The adverse events rate and compliance of VA dual therapy were 17.5% and 96%, respectively. The efficacy of VA dual therapy was superior to proton pump inhibitors\u2010based triple therapy (82.0% vs. 71.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) but lower than vonoprazan\u2010containing quadruple therapy (83.1% vs. 93.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). 7\u2010day VA dual therapy showed lower eradication rates than 10\u2010day (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200924.09, <jats:italic>p\u2009&lt;<\/jats:italic>\u20090.01) and 14\u2010day VA dual therapy (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200911.87, <jats:italic>p\u2009&lt;<\/jats:italic>\u20090.01). The adverse events rate of VA dual therapy was lower than vonoprazan triple therapy (24.6% vs. 30.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and bismuth\u2010containing quadruple therapy (20.5% vs. 47.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No significant difference of compliance was observed between VA dual therapy and each subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VA dual therapy, a novel regimen, showed high efficacy as the first\u2010line treatment for <jats:italic>H. pylori<\/jats:italic> eradication, which should be optimized before application in different regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13039","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T04:21:15Z","timestamp":1701404475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Vonoprazan and amoxicillin dual therapy as the first\u2010line treatment of <i>Helicobacter pylori<\/i> infection: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Ren\u2010Chun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"HuanKui Academy Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Xin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"The First Clinical Medical College of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobin","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"Department of Oncology Mayo Clinic  Rochester Minnesota 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-551X","authenticated-orcid":false,"given":"Nong\u2010Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"Department of Surgery The Chinese University of Hong Kong  Shatin 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