{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:37:01Z","timestamp":1792100221377,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273084"],"award-info":[{"award-number":["82273084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>\n                      Recently, vonoprazan\u2010amoxicillin (VA) dual therapy has been reported as a promising approach for\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) eradication. However, the effects of VA therapy versus bismuth\u2010containing quadruple therapy (BQT) on\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication remains unclear. The objective of this meta\u2010analysis was to compare the effects of VA dual therapy with BQT for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive search of the literature was conducted from the beginning to September 2023, utilizing PubMed, Embase, the Cochrane Library and Web of Science database. A random\u2010effects model was used to perform a meta\u2010analysis to determine the pooled relative risk (RR) with 95% confidence intervals (CIs). Moreover, trial sequential analysis (TSA) was conducted to evaluate the conclusiveness of the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six randomized controlled trials (RCTs) with 1233 patients were included. The VA therapy has similar eradication rate (ITT analysis: 87% vs. 85.7%, RR\u2009=\u20091.01, 95% CI: 0.93\u20131.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.84; PP analysis: 92.5% vs. 93.2%, RR\u2009=\u20091.00, 95% CI: 0.94\u20131.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.97) and compliance (RR\u2009=\u20091.01, 95% CI: 0.99\u20131.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.32) compared to BQT. The VA therapy group had a significantly lower incidence of total adverse events than the BQT group (16.3% vs. 40.0%, RR\u2009=\u20090.45, 95% CI: 0.37\u20130.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). The TSA result showed that the effect was conclusive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Current evidence indicated that VA therapy is just as successful as BQT in eliminating\n                      <jats:italic>H. pylori<\/jats:italic>\n                      , yet it has fewer adverse events and similar compliance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13040","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T16:48:08Z","timestamp":1700585288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Vonoprazan\u2010amoxicillin dual therapy versus bismuth\u2010containing quadruple therapy for\n                    <i>Helicobacter pylori<\/i>\n                    eradication: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-3034","authenticated-orcid":false,"given":"Ben\u2010Gang","family":"Zhou","sequence":"first","affiliation":[{"name":"Dalian Medical University  Dalian China"},{"name":"Department of Gastroenterology Affiliated Hospital of Yangzhou University, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Yangzhou University, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Bing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Yangzhou University, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"She","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Yangzhou University, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Hospital of Yangzhou University, Yangzhou University  Yangzhou 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