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Therefore, we performed a meta\u2010analysis to estimate the effect of <jats:italic>H. pylori<\/jats:italic> eradication on AG and IM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, Web of Science and EMBASE datasets through April 2023 for epidemiological studies, which provided mean glandular atrophy (GA) or IM score before and after <jats:italic>H. pylori<\/jats:italic> eradication, or provided ORs, RRs or HRs and 95% CIs for the association of AG or IM with <jats:italic>H. pylori<\/jats:italic> eradication. Weighted mean difference (WMD) and pooled ORs and 95%CIs were used to estimate the effect of <jats:italic>H. pylori<\/jats:italic> eradication on AG and IM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty articles with a total of 5242 participants were included in this meta\u2010analysis. <jats:italic>H. pylori<\/jats:italic> eradication significantly decreased GA score in the antrum (WMD \u22120.36; 95% CI: \u22120.52, \u22120.19, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), GA score in the corpus (WMD \u22120.35; 95% CI: \u22120.52, \u22120.19, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), IM score in the antrum (WMD \u22120.16; 95% CI: \u22120.26, \u22120.07, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and IM score in the corpus (WMD \u22120.20; 95% CI: \u22120.37, \u22120.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). <jats:italic>H. pylori<\/jats:italic> eradication significantly improved AG (pooled OR 2.96; 95% CI: 1.70, 5.14, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and IM (pooled OR 2.41; 95% CI: 1.24, 4.70, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The association remained significant in the subgroup analyses by study design, sites of lesions, regions and follow\u2010up time. Although Publication bias was observed for AG, the association remained significant after trim\u2010and\u2010fill adjustment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> eradication could significantly improve AG and IM at early stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hel.13042","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T09:15:31Z","timestamp":1701249331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Do atrophic gastritis and intestinal metaplasia reverse after <i>Helicobacter pylori<\/i> eradication?"],"prefix":"10.1111","volume":"29","author":[{"given":"Yongqiang","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shenzhen Qianhai Shekou Free Trade Zone Hospital  Shenzhen Guangdong People's Republic of China"},{"name":"Department of Epidemiology and 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Guangdong People's Republic of China"},{"name":"2020 Preventive Medicine, School of Public Health Shenzhen University Health Science Centre  Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Shenzhen University Health Science Centre  Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen Qianhai Shekou Free Trade Zone Hospital  Shenzhen Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and 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