{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:34:28Z","timestamp":1792427668932,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000531"],"award-info":[{"award-number":["82000531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360118"],"award-info":[{"award-number":["82360118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We previously optimized the duration and dose of vonoprazan and amoxicillin dual therapy in China. The efficacy of vonoprazan with b.i.d. amoxicillin in comparison with vonoprazan\u2010containing quadruple therapy as the first\u2010line treatment of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection has not been adequately evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a non\u2010inferiority, randomized clinical trial,\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      infected and treatment\u2010na\u00efve patients were randomly assigned to receive 14\u2009days of either vonoprazan dual (vonoprazan 20\u2009mg and amoxicillin 1\u2009g\u2009twice daily) or quadruple therapy (vonoprazan 20\u2009mg\u2009+\u2009amoxicillin 1\u2009g\u2009+\u2009furazolidone 100\u2009mg\u2009+\u2009bismuth potassium citrate 600\u2009mg twice daily).\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      status was confirmed using\n                      <jats:sup>13<\/jats:sup>\n                      C\u2010urea breath tests or fecal antigen test. The primary outcome was the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication rate following vonoprazan dual and quadruple therapy at 4\u201312\u2009weeks. We also compared drug compliance to either regimen and documented their side effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 190 subjects were randomized. The eradication rate of vonoprazan dual and quadruple therapy were 87.4% and 92.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.23) by intention\u2010to\u2010treat analysis, respectively, and 96.5% and 97.7% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.63) by per\u2010protocol analysis, respectively. The efficacy of vonoprazan dual therapy was non\u2010inferior to vonoprazan\u2010containing quadruple therapy in per\u2010protocol analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; difference: \u22121.2%; 90% confidence interval: \u22125.4% to 3.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Vonoprazan with b.i.d. amoxicillin for 14\u2009days provided similar satisfactory efficacy with vonoprazan\u2010containing quadruple therapy as a first\u2010line\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      treatment in China.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.13045","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T22:44:47Z","timestamp":1706136287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vonoprazan and amoxicillin dual therapy for 14\u2009days as the first\u2010line treatment of\n                    <i>Helicobacter pylori<\/i>\n                    infection: A non\u2010inferiority, randomized clinical trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Yi","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"Department of Surgery The Chinese University of Hong Kong  Shatin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u2010Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin\u2010Bin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Bo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"Department of Gastroenterology Shenzhen hospital of The First Affiliated Hospital of Nanchang University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-5742","authenticated-orcid":false,"given":"Xu","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-9730","authenticated-orcid":false,"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-551X","authenticated-orcid":false,"given":"Nong\u2010Hua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00431-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-328965"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002546"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325630"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12496"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12591"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311019"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319954"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.055"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1049908"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12970"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01074-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.87802"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12475"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.03.026"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01709-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502287"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12852"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12896"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-4133"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002086"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12692"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-07886-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.38.4.5436"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13003"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231190976"},{"issue":"780","key":"e_1_2_10_30_1","first-page":"e5","article-title":"Primary antibiotic resistance of Helicobacter pylori in Chinese patients: a multiregion prospective 7\u2010year study","volume":"24","author":"Liu DS","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12940"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.13166"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15837"},{"key":"e_1_2_10_34_1","article-title":"Vonoprazan and amoxicillin dual therapy as the first\u2010line treatment of Helicobacter pylori infection: a systematic review and meta\u2010analysis","author":"Du RC","year":"2023","journal-title":"Helicobacter"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13588"},{"key":"e_1_2_10_36_1","first-page":"5027","article-title":"A retrospective study of the antibiotic\u2010resistant phenotypes and genotypes of Helicobacter pylori strains in China","volume":"11","author":"Zhong Z","year":"2021","journal-title":"Am J Cancer Res"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.13045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:43:12Z","timestamp":1745628192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.13045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/hel.13045"],"URL":"https:\/\/doi.org\/10.1111\/hel.13045","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13045"}}